Histoplasmoma, pleural fibrosis, and slowly enlarging pleural effusion in an asymptomatic patient.

A slowly enlarging pleural effusion and significant pleural fibrosis occurred in an asymptomatic patient with a subpleural histoplasmoma. The pleural disease may be a reaction to antigen diffusing into the pleural space from the histoplasmoma. In selected patients, resection of the histoplasmoma may be necessary to prevent impairment of ventilation from pleural fibrosis.