Literature DB >> 3813045

The use of ketotifen, a mast cell blocker, for treatment of oligo- and asthenozoospermia.

W B Schill, J Schneider, J Ring.   

Abstract

Treatment of idiopathic oligo- and asthenozoospermia by the mast cell blocker Ketotifen leads to a very moderate, but statistical significant improvement of sperm count and sperm motility. However, pregnancy rate was within the range of spontaneous conceptions. To evaluate the possible significance of this new treatment approach further research is mandatory to elucidate the relationship between mast cell proliferation and dysfunction of the blood-testis barrier.

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Year:  1986        PMID: 3813045     DOI: 10.1111/j.1439-0272.1986.tb01831.x

Source DB:  PubMed          Journal:  Andrologia        ISSN: 0303-4569            Impact factor:   2.775


  7 in total

Review 1.  Management strategies for male factor infertility.

Authors:  Gerhard Haidl
Journal:  Drugs       Date:  2002       Impact factor: 9.546

Review 2.  Guidelines for drug treatment of male infertility.

Authors:  G Haidl; W B Schill
Journal:  Drugs       Date:  1991-01       Impact factor: 9.546

3.  Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders.

Authors:  Mónica B Frungieri; Stephan Weidinger; Viktor Meineke; Frank M Köhn; Artur Mayerhofer
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-23       Impact factor: 11.205

4.  Oxidative stress and antioxidants for idiopathic oligoasthenoteratospermia: Is it justified?

Authors:  Ashok Agarwal; Lucky H Sekhon
Journal:  Indian J Urol       Date:  2011-01

5.  Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord.

Authors:  Diego Moreno; Cristian M Sobarzo; Livia Lustig; Marcelo G Rodríguez Peña; Vanesa Anabella Guazzone
Journal:  Asian J Androl       Date:  2020 Jan-Feb       Impact factor: 3.285

Review 6.  Mast Cells in the Mammalian Testis and Epididymis-Animal Models and Detection Methods.

Authors:  Marta Himelreich-Perić; Ana Katušić-Bojanac; Marko Hohšteter; Nino Sinčić; Vedrana Mužić-Radović; Davor Ježek
Journal:  Int J Mol Sci       Date:  2022-02-25       Impact factor: 5.923

7.  Ketotifen, a mast cell blocker improves sperm motility in asthenospermic infertile men.

Authors:  Nasrin Saharkhiz; Roshan Nikbakht; Masoud Hemadi
Journal:  J Hum Reprod Sci       Date:  2013-01
  7 in total

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