| Literature DB >> 3812550 |
Abstract
Deoxyuridine (dU) increases chromosome breakage at folic acid (FA)-sensitive common fragile sites (mostly 3p14 and 16q23) in human lymphocytes. This dU-related increase can be suppressed by thymidine or FA. These results suggest that the mechanism of fragile site expression in low FA medium involves misincorporation of dU into DNA.Entities:
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Year: 1987 PMID： 3812550 DOI： 10.1002/ajmg.1320260102
Source DB: PubMed Journal: Am J Med Genet ISSN： 0148-7299