Literature DB >> 3810698

Novel derivatives of 3 alpha,7 alpha-dihydroxy-5 beta-cholan-24-oic acid (chenodeoxycholic acid) and 3 alpha,7 beta-dihydroxy-5 beta-cholan-24-oic acid (ursodeoxycholic acid).

D Kritchevsky, G Poli, C Scolastico, C R Sirtori.   

Abstract

Several 7-acyl cheno- and ursodeoxycholic acids were obtained in good yields starting from the corresponding cheno- and ursodeoxycholic acids, by a diacylation-selective hydrolysis procedure. A superior method for the synthesis of the 7-oleyl derivatives, by a selective acylation procedure, is also presented.

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Year:  1986        PMID： 3810698     DOI： 10.1016/0039-128x(86)90075-9

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  4 in total

1.  Structural requirements of bile acid transporters: C-3 and C-7 modifications of steroidal hydroxyl groups.

Authors:  Vidula Kolhatkar; James E Polli
Journal:  Eur J Pharm Sci       Date:  2012-03-03       Impact factor: 4.384

2.  Fatty acid bile acid conjugates (FABACs)--new molecules for the prevention of cholesterol crystallisation in bile.

Authors:  T Gilat; G J Somjen; Y Mazur; A Leikin-Frenkel; R Rosenberg; Z Halpern; F Konikoff
Journal:  Gut       Date:  2001-01       Impact factor: 23.059

Review 3.  Chemical and metabolic transformations of selected bile acids.

Authors:  K Kuhajda; S Kevresan; J Kandrac; J P Fawcett; M Mikov
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2006 Jul-Sep       Impact factor: 2.441

4.  Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice.

Authors:  T Gilat; A Leikin-Frenkel; L Goldiner; H Laufer; Z Halpern; F M Konikoff
Journal:  Lipids       Date:  2001-10       Impact factor: 1.880
  4 in total

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