Literature DB >> 3810655

The relative importance of N-oxidation and N-demethylation in the metabolism of trimethylamine in man.

M Al-Waiz, S C Mitchell, J R Idle, R L Smith.   

Abstract

The metabolism of orally administered trimethylamine has been studied in 4 male volunteers at 2 dose levels. N-Oxidation was the major route of metabolism whilst N-demethylation was negligible and only significant at the higher dose level.

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Year:  1987        PMID： 3810655     DOI： 10.1016/0300-483x(87)90001-1

Source DB:  PubMed          Journal:  Toxicology        ISSN： 0300-483X            Impact factor:   4.221


  4 in total

1.  Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.

Authors:  W H Wilson Tang; Zeneng Wang; Bruce S Levison; Robert A Koeth; Earl B Britt; Xiaoming Fu; Yuping Wu; Stanley L Hazen
Journal:  N Engl J Med       Date:  2013-04-25       Impact factor: 91.245

2.  Experimental study on the metabolism of dimethylethylamine in man.

Authors:  B Ståhlbom; T Lundh; B Akesson
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

3.  NMR-Based Metabolomic Analysis for the Effects of Trimethylamine N-Oxide Treatment on C2C12 Myoblasts under Oxidative Stress.

Authors:  Hong Zou; Caihua Huang; Lin Zhou; Ruohan Lu; Yimin Zhang; Donghai Lin
Journal:  Biomolecules       Date:  2022-09-13

Review 4.  Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.

Authors:  Diede Fennema; Ian R Phillips; Elizabeth A Shephard
Journal:  Drug Metab Dispos       Date:  2016-05-17       Impact factor: 3.922
  4 in total

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