Literature DB >> 3810169

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

D Goldgaber, M I Lerman, O W McBride, U Saffiotti, D C Gajdusek.   

Abstract

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.

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Year:  1987        PMID： 3810169     DOI： 10.1126/science.3810169

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  299 in total

Review 1.  Presenilins: structural aspects and posttranslational events.

Authors:  F Checler
Journal:  Mol Neurobiol       Date:  1999-06       Impact factor: 5.590

2.  Amyloid in the brains of aged squirrel monkeys.

Authors:  L C Walker; C Masters; K Beyreuther; D L Price
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

3.  Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis.

Authors:  W Sue T Griffin; Steven W Barger
Journal:  US Neurol       Date:  2010

4.  Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease.

Authors:  J Ghiso; T Wisniewski; R Vidal; A Rostagno; B Frangione
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

Review 5.  Alzheimer's disease.

Authors:  M Rossor
Journal:  Postgrad Med J       Date:  1992-07       Impact factor: 2.401

6.  Alzheimer disease: the new agenda.

Authors:  J Hardy; M C Chartier-Harlin; M Mullan
Journal:  Am J Hum Genet       Date:  1992-03       Impact factor: 11.025

7.  The physiological functions of the β-amyloid precursor protein APP.

Authors:  Ulrike C Müller; Claus U Pietrzik; Thomas Deller
Journal:  Exp Brain Res       Date:  2012-04       Impact factor: 1.972

8.  Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease.

Authors:  H V Vinters; G S Nishimura; D L Secor; W M Pardridge
Journal:  Am J Pathol       Date:  1990-08       Impact factor: 4.307

9.  Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells.

Authors:  G M Cole; T V Huynh; T Saitoh
Journal:  Neurochem Res       Date:  1989-10       Impact factor: 3.996

Review 10.  Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease.

Authors:  A J Rozemuller; R A Roos; G T Bots; W Kamphorst; P Eikelenboom; W E Van Nostrand
Journal:  Am J Pathol       Date:  1993-05       Impact factor: 4.307
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