Literature DB >> 3810001

Effect of cimetidine on gastric mucosal cell proliferation in man.

L B Svendsen, O H Hansen, J K Larsen, T Pedersen, A Johansen.   

Abstract

Seven duodenal ulcer patients were treated for 3 months with cimetidine. Before and after treatment endoscopic biopsy specimens were taken for autoradiographic estimation of cell proliferation in the gastric mucosa in the antral and fundic part of the stomach and from the duodenum. In all three areas the estimated labeling index was increased during medication with cimetidine. The increase in epithelial cell renewal may participate in the ulcer healing effect of cimetidine.

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Year:  1986        PMID: 3810001     DOI: 10.3109/00365528608996454

Source DB:  PubMed          Journal:  Scand J Gastroenterol        ISSN: 0036-5521            Impact factor:   2.423


  2 in total

Review 1.  Histamine H2-receptor antagonists versus prostaglandins in the treatment of peptic ulcer disease.

Authors:  J G Penston; K G Wormsley
Journal:  Drugs       Date:  1989-04       Impact factor: 9.546

2.  Effect of aging on gastric mucosal proliferation in rats treated with aspirin.

Authors:  Y Twersky; M Blumstein; S Bank; V Kranz
Journal:  Dig Dis Sci       Date:  1995-03       Impact factor: 3.199

  2 in total

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