Literature DB >> 3809216

Intra-nucleus accumbens amphetamine: dose-dependent effects on food intake.

K R Evans, F J Vaccarino.   

Abstract

The effects of microinjections into the nucleus accumbens (N.ACC.) of 0.0, 2.0 or 8.0 micrograms of (+)-amphetamine sulphate (AMPH) on food intake and running wheel activity were examined. The 2.0 micrograms dose of AMPH produced increased food intake while 8.0 micrograms significantly decreased food intake. No effect was found on running wheel activity with the 2.0 micrograms dose, though 8.0 micrograms significantly increased the number of wheel revolutions with respect to the saline group. Results were interpreted to suggest that the N.ACC. may be an important site in the mediation of the increased food intake noted with low doses of psychomotor stimulants.

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Year:  1986        PMID： 3809216     DOI： 10.1016/0091-3057(86)90102-4

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  16 in total

1.  Reduced accumbens dopamine in Sprague-Dawley rats prone to overeating a fat-rich diet.

Authors:  Pedro Rada; Miriam E Bocarsly; Jessica R Barson; Bartley G Hoebel; Sarah F Leibowitz
Journal:  Physiol Behav       Date:  2010-07-16

2.  Role of dopamine D-1 and D-2 receptor subtypes in mediating dopamine agonist effects on food consumption in rats.

Authors:  M T Martin-Iverson; C T Dourish
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

3.  D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell.

Authors:  B Kalyanasundar; Claudia I Perez; Alvaro Luna; Jessica Solorio; Mario G Moreno; David Elias; Sidney A Simon; Ranier Gutierrez
Journal:  J Neurophysiol       Date:  2015-05-13       Impact factor: 2.714

Review 4.  Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use.

Authors:  Jessica R Barson; Irene Morganstern; Sarah F Leibowitz
Journal:  ILAR J       Date:  2012

5.  Amphetamine Dose-Dependently Decreases and Increases Binge Intake of Fat and Sucrose Independent of Sex.

Authors:  Katherine Stuhrman West; Valen Lawson; Andrew M Swanson; Anna I Dunigan; Aaron G Roseberry
Journal:  Obesity (Silver Spring)       Date:  2019-09-27       Impact factor: 5.002

Review 6.  The tempted brain eats: pleasure and desire circuits in obesity and eating disorders.

Authors:  Kent C Berridge; Chao-Yi Ho; Jocelyn M Richard; Alexandra G DiFeliceantonio
Journal:  Brain Res       Date:  2010-04-11       Impact factor: 3.252

7.  Analysis of the effects of intra-accumbens SKF-38393 and LY-171555 upon the behavioural satiety sequence.

Authors:  G D Phillips; S R Howes; R B Whitelaw; T W Robbins; B J Everitt
Journal:  Psychopharmacology (Berl)       Date:  1995-01       Impact factor: 4.530

8.  Individual differences in the feeding effects of amphetamine: role of nucleus accumbens dopamine and circadian factors.

Authors:  T L Sills; J P Baird; F J Vaccarino
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Alpha-melanocyte stimulating hormone increases the activity of melanocortin-3 receptor-expressing neurons in the ventral tegmental area.

Authors:  Katherine Stuhrman West; Chunxia Lu; David P Olson; Aaron G Roseberry
Journal:  J Physiol       Date:  2019-05-26       Impact factor: 5.182

10.  Facilitation and inhibition of feeding by a single dose of amphetamine: relationship to baseline intake and accumbens cholecystokinin.

Authors:  T L Sills; F J Vaccarino
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
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