Management of primary herpes in pregnancy complicated by ruptured membranes and extreme prematurity: case report.

A case of primary herpes simplex vaginitis during pregnancy became complicated by rupture of membranes at 25.5 weeks' gestation. The patient was treated with intravenous acyclovir shortly after rupture, and managed expectantly. Genital lesions rapidly abated, and the infant was delivered by cesarean section at 26.5 weeks' gestation after labor ensued. Transplacental passage of acyclovir was documented. The infant then was treated with a ten-day course of intravenous acyclovir. The infant has remained culture negative for 12 months after delivery.