| Literature DB >> 3806595 |
R A Coburn, M T Clark, R T Evans, R J Genco.
Abstract
A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.Entities:
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Year: 1987 PMID： 3806595 DOI： 10.1021/jm00384a035
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446