Literature DB >> 3806584

Basically substituted ellipticine analogues as potential antitumor agents.

L M Werbel, M Angelo, D W Fry, D F Worth.   

Abstract

Installation of a basic side chain on the ring nitrogen of ellipticine did, as expected, improve the DNA binding properties of these molecules as measured by an ethidium displacement assay. In vivo antitumor activity was not, however, improved.

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Year:  1986        PMID: 3806584     DOI: 10.1021/jm00157a040

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  2 in total

1.  C4-substituted isoquinolines: synthesis and cytotoxic action.

Authors:  A Tsotinis; S Zouroudis; D Moreau; C Roussakis
Journal:  Open Med Chem J       Date:  2007-07-19

2.  Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives.

Authors:  Hatem A Abuelizz; Rashad Al-Salahi; Jamil Al-Asri; Jérémie Mortier; Mohamed Marzouk; Essam Ezzeldin; Azza A Ali; Mona G Khalil; Gerhard Wolber; Hazem A Ghabbour; Abdulrahman A Almehizia; Gehad A Abdel Jaleel
Journal:  Chem Cent J       Date:  2017-10-16       Impact factor: 4.215

  2 in total

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