Literature DB >> 380619

Effects of high doses of a series of new luteinizing hormone-releasing hormone analogues in intact female rats.

P V Maynard, R I Nicholson.   

Abstract

A new series of LH-RH analogues containing an Azgly10 modification and having potent agonist properties were given in high concentration to intact female rats. Plasma LH and FSH were raised to extremely high levels after 14 days' administration of the compounds (5.0 and 0.5 microgram/rat twice daily), but plasma oestradiol concentrations were reduced to those in ovariectomized rats. The weights of the ovary and uterus were also markedly reduced, suggesting that these compounds are, on this treatment regime, producing the effects of chemical castration.

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Year:  1979        PMID： 380619      PMCID： PMC2009871          DOI： 10.1038/bjc.1979.51

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  8 in total

1.  Regression of corpora lutea in the rabbit after injection of a gonadotropin-releasing peptide.

Authors:  R H Rippel; E S Johnson; E T Kimura
Journal:  Proc Soc Exp Biol Med       Date:  1976-05

2.  Potent agonist and antagonist analogues of luliberin containing an azaglycine residue in position 10.

Authors:  A S Dutta; B J Furr; M B Giles; B Valcaccia; A L Walpole
Journal:  Biochem Biophys Res Commun       Date:  1978-03-30       Impact factor: 3.575

Review 3.  The measurement of human gonadotrophins by radioimmunoassay.

Authors:  G V Groom
Journal:  J Reprod Fertil       Date:  1977-09

4.  Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence.

Authors:  H Matsuo; Y Baba; R M Nair; A Arimura; A V Schally
Journal:  Biochem Biophys Res Commun       Date:  1971-06-18       Impact factor: 3.575

5.  Ovulation and gonadotropin-releasing activity of [p-LEU-6, DES-GLY NH2-10, pro-ethylamide-9] -GNRH.

Authors:  R H Rippel; E S Johnson; W F White; M Fujino; T Fukuda; S Kobayashi
Journal:  Proc Soc Exp Biol Med       Date:  1975-04

6.  Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses.

Authors:  Y Baba; H Matsuo; A V Schally
Journal:  Biochem Biophys Res Commun       Date:  1971-07-16       Impact factor: 3.575

7.  Synthesis and biological activity of highly active alpha-aza analogues of luliberin.

Authors:  A S Dutta; B J Furr; M B Giles; B Valcaccia
Journal:  J Med Chem       Date:  1978-10       Impact factor: 7.446

8.  Anti-tumour activity of ICI 118630, a new potent luteinizing hormone-releasing hormone agonist.

Authors:  R I Nicholson; P V Maynard
Journal:  Br J Cancer       Date:  1979-03       Impact factor: 7.640
  8 in total
  5 in total

1.  Unresponsiveness of the reproductive organs of the male mouse to treatment with a potent luteinizing hormone-releasing hormone agonist (ICI-118,630).

Authors:  G J van Steenbrugge; J C Romijn; F H de Jong; F H Schröder
Journal:  Urol Res       Date:  1984

2.  The use of an LH-RH agonist (ICI 118630, Zoladex) in advanced premenopausal breast cancer.

Authors:  M R Williams; K J Walker; A Turkes; R W Blamey; R I Nicholson
Journal:  Br J Cancer       Date:  1986-05       Impact factor: 7.640

3.  Anti-tumour activity of ICI 118630, a new potent luteinizing hormone-releasing hormone agonist.

Authors:  R I Nicholson; P V Maynard
Journal:  Br J Cancer       Date:  1979-03       Impact factor: 7.640

4.  From contraception to cancer: a review of the therapeutic applications of LHRH analogues as antitumor agents.

Authors:  A Corbin
Journal:  Yale J Biol Med       Date:  1982 Jan-Feb

5.  Effects of a gonadotropin-releasing hormone agonist on rat ovarian adenocarcinoma cell lines in vitro and in vivo.

Authors:  T Maruuchi; T Sugiyama; A Kataoka; T Nishida; M Yakushiji
Journal:  Jpn J Cancer Res       Date:  1998-09
  5 in total

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