Literature DB >> 3806112

The in-vitro chemosensitivity of three cell lines derived from the VM/DK spontaneous murine astrocytoma.

R Bradford, J L Darling, D G Thomas.   

Abstract

Three cell lines, VM/Dk P497 P540 and P560 derived from the VM spontaneous murine astrocytoma have previously been fully characterised and found to differ in their degree of astrocytic differentiation. The in vitro chemosensitivity of the three lines has been investigated using the 35S-methionine uptake assay. Differential chemosensitivity was found to exist between the cell lines. The pattern of chemosensitivity in relation to astrocytic differentiation was complex but the least differentiated cell line, P497, tended to be the least chemosensitive.

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Year:  1986        PMID： 3806112      PMCID： PMC1029119          DOI： 10.1136/jnnp.49.12.1361

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  25 in total

1.  Differential response by human melanoma cells to 1,3-bis-(2-chloroethyl)-1-nitrosourea and bleomycin.

Authors:  S C Berranco; B Drewinko; R M Humphrey
Journal:  Mutat Res       Date:  1973-08       Impact factor: 2.433

2.  Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells.

Authors:  K Dano
Journal:  Biochim Biophys Acta       Date:  1973-10-25

3.  Differential sensitivites of human melanoma cells grown in vitro to arabinosylcytosine.

Authors:  S C Barranco; D H Ho; B Drewinko; M M Romsdahl; R M Humphrey
Journal:  Cancer Res       Date:  1972-12       Impact factor: 12.701

4.  Studies on the chemotherapy of experimental brain tumors: development of an experimental model.

Authors:  J I Ausman; W R Shapiro; D P Rall
Journal:  Cancer Res       Date:  1970-09       Impact factor: 12.701

5.  The effects of beta-2'-deoxythioguanosine on survival and progression in mammalian cells.

Authors:  S C Barranco; R M Humphrey
Journal:  Cancer Res       Date:  1971-05       Impact factor: 12.701

6.  Mechanism of cross-resistance between vincristine and daunorubicin in Ehrlich ascites tumor cells.

Authors:  T Skovsgaard
Journal:  Cancer Res       Date:  1978-12       Impact factor: 12.701

7.  Membrane-mediated drug resistance and phenotypic reversion to normal growth behavior of Chinese hamster cells.

Authors:  J L Biedler; H Riehm; R H Peterson; B A Spengler
Journal:  J Natl Cancer Inst       Date:  1975-09       Impact factor: 13.506

8.  Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.

Authors:  G H Heppner; D L Dexter; T DeNucci; F R Miller; P Calabresi
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

9.  Development of an in vitro colony formation assay for the evaluation of in vivo chemotherapy of a rat brain tumor.

Authors:  M L Rosenblum; K D Knebel; K T Wheeler; M Barker; C B Wilson
Journal:  In Vitro       Date:  1975 Sep-Oct

10.  Tumorigenicity of cell lines (VMDk) derived from a spontaneous murine astrocytoma. Histology, fine structure and immunocytochemistry of tumours.

Authors:  G J Pilkington; J L Darling; P L Lantos; D G Thomas
Journal:  J Neurol Sci       Date:  1985-12       Impact factor: 3.181
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  2 in total

1.  The VM model of glioma: preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy.

Authors:  R Bradford; J L Darling; N Sier; D G Thomas
Journal:  J Neurooncol       Date:  1990-10       Impact factor: 4.130

2.  Heterogeneity of chemosensitivity in six clonal cell lines derived from a spontaneous murine astrocytoma and its relationship to genotypic and phenotypic characteristics.

Authors:  R Bradford; H Koppel; G J Pilkington; D G Thomas; J L Darling
Journal:  J Neurooncol       Date:  1997-09       Impact factor: 4.130
  2 in total

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