Literature DB >> 3806082

Iron, a new aid in the treatment of Parkinson patients.

W Birkmayer, J G Birkmayer.   

Abstract

One of the problems in treating Parkinson patients is the so called "off-effect" which occurs after long term treatment with L-DOPA. Off-effects are characterized by severe rigor and akinesia. Increasing dosages of L-DOPA and decarboxylase- or monoaminooxidase-inhibitors do not improve these symptoms. Intravenously applied iron--in form of a ferri-ferro-complex--exhibited a considerable benefit for all patients treated so far. They regained a remarkable mobility. Their disability score dropped from up to 90% down to 30%. The effect of iron is dosage-dependent and lasts 24 to 48 hours.

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Year:  1986        PMID： 3806082     DOI： 10.1007/bf01243354

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  7 in total

1.  The potentiation of the anti akinetic effect after L-dopa treatment by an inhibitor of MAO-B, Deprenil.

Authors:  W Birkmayer; P Riederer; M B Youdim; W Linauer
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

2.  On the presence of 3-hydroxytyramine in brain.

Authors:  A CARLSSON; M LINDQVIST; T MAGNUSSON; B WALDECK
Journal:  Science       Date:  1958-02-28       Impact factor: 47.728

3.  3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists.

Authors:  A CARLSSON; M LINDQVIST; T MAGNUSSON
Journal:  Nature       Date:  1957-11-30       Impact factor: 49.962

Review 4.  [Modern treatment of parkinsonism].

Authors:  W Birkmayer; E Neumayer
Journal:  Z Neurol       Date:  1972

5.  [Experimental results of the combined treatment of parkinsonism using L-DOPA and a decarboxylase inhibitory agent (Ro 4-4602)].

Authors:  W Birkmayer
Journal:  Wien Klin Wochenschr       Date:  1969-09-26       Impact factor: 1.704

6.  Biopterin in human brain and urine from controls and parkinsonian patients: application of a new radioimmunoassay.

Authors:  T Nagatsu; T Yamaguchi; T Kato; T Sugimoto; S Matsuura; M Akino; I Nagatsu; R Iizuka; H Narabayashi
Journal:  Clin Chim Acta       Date:  1981-02-05       Impact factor: 3.786

7.  [The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].

Authors:  W BIRKMAYER; O HORNYKIEWICZ
Journal:  Wien Klin Wochenschr       Date:  1961-11-10       Impact factor: 1.704
  7 in total
  3 in total

1.  Effect of L-dopa, oxyferriscorbone and ferrous iron on in vivo lipid peroxidation.

Authors:  P Dostert; M S Benedetti; E Frigerio
Journal:  J Neural Transm Gen Sect       Date:  1991

Review 2.  Is NADH effective in the treatment of Parkinson's disease?

Authors:  R H Swerdlow
Journal:  Drugs Aging       Date:  1998-10       Impact factor: 3.923

3.  Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain.

Authors:  E Sofic; P Riederer; H Heinsen; H Beckmann; G P Reynolds; G Hebenstreit; M B Youdim
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575
  3 in total

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