Literature DB >> 3806080

Effect of oestradiol on the responses of regional brain serotonin to stress in the ovariectomized rat.

L K Chomicka.   

Abstract

The effect of oestradiol on the response of regional brain 5-hydroxytryptamine (serotonin, 5-HT) to 24 hour electrical footshock was investigated in ovariectomized rats. The stress applied four weeks after ovariectomy induced significant decreases in 5-HT concentrations in the fronto-parietal brain cortex (Bc), hippocampus (Hipp), striatum (CP), medial-basal hypothalamus (MBH) and the preoptic-anterior hypothalamic area (PAHA). Pretreatment with oestradiol prevented the footshock-induced decreases in 5-HT in the Hipp, CP, MBH and the PAHA. It was concluded that oestradiol may prevent stress-induced response of regional brain 5-HT in ovariectomized rats. An interaction between oestradiol and brain 5-HT is proposed in the control of the course of the oestrous cycles in stressful situations.

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Year:  1986        PMID： 3806080     DOI： 10.1007/bf01243352

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  22 in total

1.  Changes in biogenic amine synthesis and turnover induced by hypoxia and/or foot shock stress. II. The central nervous system.

Authors:  R M Brown; S R Snider; A Carlsson
Journal:  J Neural Transm       Date:  1974       Impact factor: 3.575

2.  Metabolism of norepinephrine, serotonin and dopamine in rat brain with stress.

Authors:  E L Bliss; J Ailion; J Zwanziger
Journal:  J Pharmacol Exp Ther       Date:  1968-11       Impact factor: 4.030

3.  The effect of ovarian steroids on the accumulation of 3H-labelled monoamines by hypothalamic tissue in vitro.

Authors:  C A Endersby; C A Wilson
Journal:  Brain Res       Date:  1974-06-20       Impact factor: 3.252

4.  Ovulation and mating behavior in female rats under various environmental stresses or androgen treatment.

Authors:  N Hagino
Journal:  Jpn J Physiol       Date:  1968-06-15

5.  Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain.

Authors:  G Curzon; A R Green
Journal:  Br J Pharmacol       Date:  1970-07       Impact factor: 8.739

6.  Serotonin-reinstatement of luteinizing hormone surges after loss of positive feedback in ovariectomized rats bearing subcutaneous capsules containing oestrogen.

Authors:  R F Walker
Journal:  J Endocrinol       Date:  1983-07       Impact factor: 4.286

7.  Serotonin receptor concentration during the estrous cycle of the rat.

Authors:  A Biegon; H Bercovitz; D Samuel
Journal:  Brain Res       Date:  1980-04-07       Impact factor: 3.252

8.  Serotonin and tryptophan hydroxylase in isolated hypothalamic and brain stem nuclei of rats exposed to acute and repeated immobilization stress.

Authors:  J Culman; A Kiss; R Kvetnanský
Journal:  Exp Clin Endocrinol       Date:  1984-03

9.  Daily variations in serotonin metabolism in the suprachiasmatic nucleus of the rat: influence of oestradiol impregnation.

Authors:  M Héry; M Faudon; G Dusticier; F Héry
Journal:  J Endocrinol       Date:  1982-08       Impact factor: 4.286

10.  Cellular mechanisms of acute estrogen negative feedback on LH secretion: norepinephrine, dopamine and 5-hydroxytryptamine metabolism in discrete regions of the rat brain.

Authors:  C A Johnston; M Tesone; A Negro-Vilar
Journal:  Brain Res Bull       Date:  1984-09       Impact factor: 4.077
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  1 in total

1.  Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT.

Authors:  D J Haleem; G A Kennett; G Curzon
Journal:  J Neural Transm Gen Sect       Date:  1990
  1 in total

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