| Literature DB >> 3804998 |
K S Browning, D M Maia, S R Lax, J M Ravel.
Abstract
A previously unidentified factor has been isolated from wheat germ that stimulates globin mRNA-directed polypeptide synthesis in vitro. This factor is separated from eukaryotic initiation factor (eIF)-4B by chromatography on m7GTP-Sepharose. eIF-4B binds to m7GTP-Sepharose, whereas the stimulatory factor does not. Further purification of the factor yields a preparation that contains one major polypeptide with a molecular weight of approximately 59,000, This factor enhances the binding of globin mRNA to 40 S ribosomal subunits in the presence of eIF-2, eIF-3, eIF-4A, and either eIF-4B or eIF-4F and has been designated eIF-4G.Entities:
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Year: 1987 PMID： 3804998
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157