| Literature DB >> 3804882 |
Abstract
Concentrations of cefuroxime were measured in the serum and femoral and tibial bone of 12 patients undergoing knee arthroplasty, following cefuroxime 1.5 g iv. The mean serum cefuroxime concentration was 112.4 mg/l at the time of application of the mid thigh tourniquet. The mean femoral bone concentration was 18.6 mg/kg and tibial bone was 15.5 mg/kg. These concentrations of cefuroxime appear adequate for prophylaxis against post-operative infection in knee arthroplasty.Entities:
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Year: 1986 PMID： 3804882 DOI： 10.1093/jac/18.5.609
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790