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Literature DB >> 3804380

Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line.

S A Ellis, I L Sargent, C W Redman, A J McMichael.

Abstract

We describe the characterization of a novel HLA Class I molecule, which we have isolated from chorionic cytotrophoblast cell membranes, and from a trophoblast-derived choriocarcinoma cell line, BeWo; classical HLA Class I antigens are not expressed on these cells. This antigen is an electrophoretically non-polymorphic glycoprotein of approximately 40,000 molecular weight, which is found in association with beta 2 microglobulin, and which is detected by monoclonal antibodies recognizing monomorphic determinants of HLA Class I. Elucidation of the nature and origin of this molecule may provide valuable information regarding the immune barrier that exists between mother and fetus.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3804380 PMCID： PMC1453327

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

18 in total

1. A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17.

Authors: A J McMichael; P Parham; N Rust; F Brodsky
Journal: Hum Immunol Date: 1980-09 Impact factor: 2.850

2. Class 1 major histocompatibility complex antigens on human extra-villous trophoblast.

Authors: C W Redman; A J McMichael; G M Stirrat; C A Sunderland; A Ting
Journal: Immunology Date: 1984-07 Impact factor: 7.397

Review 3. Genes of the major histocompatibility complex.

Authors: L Hood; M Steinmetz; R Goodenow
Journal: Cell Date: 1982-04 Impact factor: 41.582

4. Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.

Authors: F M Brodsky; W F Bodmer; P Parham
Journal: Eur J Immunol Date: 1979-07 Impact factor: 5.532

5. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody.

Authors: A J McMichael; J R Pilch; G Galfré; D Y Mason; J W Fabre; C Milstein
Journal: Eur J Immunol Date: 1979-03 Impact factor: 5.532

6. Absence of the cancer-associated factor with a molecular weight of 60,000 from the plasma of patients with a spectrum of nonneoplastic conditions.

Authors: D E Schumm; M E Hanausek-Walaszek; Z Walaszek; T E Webb
Journal: Cancer Res Date: 1984-01 Impact factor: 12.701

7. Recognition of HLA-B27 and related antigen by a monoclonal antibody.

Authors: S A Ellis; C Taylor; A McMichael
Journal: Hum Immunol Date: 1982-08 Impact factor: 2.850

8. Definition of four HLA-A2 subtypes by CML typing and biochemical analysis.

Authors: J J van der Poel; H Mölders; A Thompson; H L Ploegh
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

9. A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin.

Authors: R W Knowles; W F Bodmer
Journal: Eur J Immunol Date: 1982-08 Impact factor: 5.532

10. Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.

Authors: S M Goyert; J E Shively; J Silver
Journal: J Exp Med Date: 1982-08-01 Impact factor: 14.307

55 in total

Review 1. The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells.

Authors: Roberta Rizzo; Martine Vercammen; Hilde van de Velde; Peter A Horn; Vera Rebmann
Journal: Cell Mol Life Sci Date: 2010-11-16 Impact factor: 9.261

2. Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor.

Authors: M Ponte; C Cantoni; R Biassoni; A Tradori-Cappai; G Bentivoglio; C Vitale; S Bertone; A Moretta; L Moretta; M C Mingari
Journal: Proc Natl Acad Sci U S A Date: 1999-05-11 Impact factor: 11.205

Evidence for a novel HLA antigen found on human extravillous trophoblast and a choriocarcinoma cell line.

1. A monoclonal antibody that recognizes an antigenic determinant shared by HLA A2 and B17.

2. Class 1 major histocompatibility complex antigens on human extra-villous trophoblast.

Review 3. Genes of the major histocompatibility complex.

4. Characterization of a monoclonal anti-beta 2-microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens.

5. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody.

6. Absence of the cancer-associated factor with a molecular weight of 60,000 from the plasma of patients with a spectrum of nonneoplastic conditions.

7. Recognition of HLA-B27 and related antigen by a monoclonal antibody.

8. Definition of four HLA-A2 subtypes by CML typing and biochemical analysis.

9. A monoclonal antibody recognizing a human thymus leukemia-like antigen associated with beta 2-microglobulin.

10. Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion molecules.

Review 1. The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells.

2. Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor.

Review 3. Disturbances in placental immunology: ready for therapeutic interventions?

4. A commentary on gestational programming and functions of HLA-G in pregnancy.

5. Expression and analysis of the rat placental class I cDNA clone encoding the Pa antigen.

6. Peripheral blood natural killer cells and mild thyroid abnormalities in women with reproductive failure.

Review 7. Regulation of fetal allograft survival by a hormone-controlled Th1- and Th2-type cytokines.

8. Membrane-bound and water-soluble nonclassical class I MHC antigens on rat placenta.

9. Ankylosing spondylitis without B27: no evidence for gene conversion.

Review 10. Maternal and fetal T cells in term pregnancy and preterm labor.