Literature DB >> 3803597

Tumour necrosis factor is a compact trimer.

P Wingfield, R H Pain, S Craig.   

Abstract

Recombinant produced human tumour necrosis factor (TNF) has been studied to characterise the subunit structure of the protein. TNF is shown to be a trimer Mr 52000 in which the subunits are associated in a compact, triangular form. In secondary structure it belongs to the all-beta class of proteins. It has high thermodynamic stability and the unfolded subunits can fold and associate spontaneously to form native, biologically active TNF.

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Year:  1987        PMID： 3803597     DOI： 10.1016/0014-5793(87)81432-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

1.  Thiolated recombinant human tumor necrosis factor-alpha protects against Plasmodium berghei K173-induced experimental cerebral malaria in mice.

Authors:  N S Postma; R C Hermsen; D J Crommelin; W M Eling; J Zuidema
Journal:  Antimicrob Agents Chemother       Date:  1999-05       Impact factor: 5.191

2.  Antibodies against amino acids 1-15 of tumor necrosis factor block its binding to cell-surface receptor.

Authors:  S H Socher; M W Riemen; D Martinez; A Friedman; J Tai; J C Quintero; V Garsky; A Oliff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  Oligomeric tumour necrosis factor alpha slowly converts into inactive forms at bioactive levels.

Authors:  A Corti; G Fassina; F Marcucci; E Barbanti; G Cassani
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

Review 4.  Sequence, structure, function, immunity: structural genomics of costimulation.

Authors:  Kausik Chattopadhyay; Eszter Lazar-Molnar; Qingrong Yan; Rotem Rubinstein; Chenyang Zhan; Vladimir Vigdorovich; Udupi A Ramagopal; Jeffrey Bonanno; Stanley G Nathenson; Steven C Almo
Journal:  Immunol Rev       Date:  2009-05       Impact factor: 12.988

5.  Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.

Authors:  Roma Stawikowska; Mare Cudic; Marc Giulianotti; Richard A Houghten; Gregg B Fields; Dmitriy Minond
Journal:  J Biol Chem       Date:  2013-06-18       Impact factor: 5.157

6.  TNFalpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve.

Authors:  Veronica I Shubayev; Mila Angert; Jennifer Dolkas; W Marie Campana; Kai Palenscar; Robert R Myers
Journal:  Mol Cell Neurosci       Date:  2005-11-16       Impact factor: 4.314

7.  Recognition of human tumor necrosis factor α (TNF-α) by therapeutic antibody fragment: energetics and structural features.

Authors:  Jaka Marušič; Črtomir Podlipnik; Simona Jevševar; Drago Kuzman; Gorazd Vesnaver; Jurij Lah
Journal:  J Biol Chem       Date:  2012-01-19       Impact factor: 5.157

8.  Lyophilized formulations of recombinant tumor necrosis factor.

Authors:  M S Hora; R K Rana; F W Smith
Journal:  Pharm Res       Date:  1992-01       Impact factor: 4.200

9.  Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages.

Authors:  Yeonsoo Joe; Hyo Jeong Kim; Sena Kim; Jiwha Chung; Myoung Seok Ko; Won Hyeok Lee; Ki Churl Chang; Jeong Woo Park; Hun Taeg Chung
Journal:  J Biol Chem       Date:  2011-05-23       Impact factor: 5.157

10.  The limited proteolysis of tumor necrosis factor-alpha.

Authors:  L O Narhi; M F Rhode; P Hunt; T Arakawa
Journal:  J Protein Chem       Date:  1989-10
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