Literature DB >> 3803575

Propylthiouracil, a selective inhibitor of NADH-cytochrome b5 reductase.

E Lee, K Kariya.   

Abstract

Propylthiouracil inhibited the activity of NADH-cytochrome b5 reductase of rat liver microsomes using potassium ferricyanide as electron acceptor. On the other hand, NADPH-cytochrome P-450 reductase activity was not affected by the compound. NADH-supported reduction of cytochrome b5 was also inhibited by propylthiouracil in the reconstituted system consisting of cytochrome b5 and partially purified NADH-cytochrome b5 reductase.

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Year:  1986        PMID： 3803575     DOI： 10.1016/0014-5793(86)81082-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.

Authors:  Md Mizanur Rahaman; Fabio G Reinders; David Koes; Anh T Nguyen; Stephanie M Mutchler; Courtney Sparacino-Watkins; Roger A Alvarez; Megan P Miller; Dongmei Cheng; Bill B Chen; Edwin K Jackson; Carlos J Camacho; Adam C Straub
Journal:  J Biol Chem       Date:  2015-05-22       Impact factor: 5.157

2.  Intracellular imaging of metmyoglobin and oxygen using new dual purpose probe EYFP-Myoglobin-mCherry.

Authors:  Rozhin Penjweini; Branden Roarke; Greg Alspaugh; Katie A Link; Alessio Andreoni; Mateus P Mori; Paul M Hwang; Dan L Sackett; Jay R Knutson
Journal:  J Biophotonics       Date:  2021-11-16       Impact factor: 3.390

3.  GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.

Authors:  Lisha Wei; Yan-Yan Zheng; Jie Sun; Pei Wang; Tao Tao; Yeqiong Li; Xin Chen; Yongjuan Sang; Danyang Chong; Wei Zhao; Yuwei Zhou; Ye Wang; Zhihui Jiang; Tiantian Qiu; Chao-Jun Li; Min-Sheng Zhu; Xuena Zhang
Journal:  J Biol Chem       Date:  2020-09-10       Impact factor: 5.157

4.  Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.

Authors:  Lu Gan; Lisa L von Moltke; Lauren A Trepanier; Jerold S Harmatz; David J Greenblatt; Michael H Court
Journal:  Drug Metab Dispos       Date:  2008-10-06       Impact factor: 3.922

5.  A metabolic modeling approach reveals promising therapeutic targets and antiviral drugs to combat COVID-19.

Authors:  Fernando Santos-Beneit; Vytautas Raškevičius; Vytenis A Skeberdis; Sergio Bordel
Journal:  Sci Rep       Date:  2021-06-07       Impact factor: 4.379

6.  Endothelial cell expression of haemoglobin α regulates nitric oxide signalling.

Authors:  Adam C Straub; Alexander W Lohman; Marie Billaud; Scott R Johnstone; Scott T Dwyer; Monica Y Lee; Pamela Schoppee Bortz; Angela K Best; Linda Columbus; Benjamin Gaston; Brant E Isakson
Journal:  Nature       Date:  2012-10-31       Impact factor: 49.962
  6 in total

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