Treatment of acute and chronic sinusitis with cefadroxil.

In an open study, 30 patients (mean age 43.7 years) with clinical and radiological evidence of sinusitis were studied by transmaxillary sinus aspirations (19 bilateral and 11 unilateral for a total of 49 aspirates). The sinus aspirations were performed with careful sterile intermeatus needle puncture techniques and the material was cultured for aerobic and anaerobic bacteria. The organisms most frequently recovered from the sinus aspirates were Gram-positive (55%), Gram-negative (33%), and anaerobes (6%). Cefadroxil 1g was given every 12 hours (2g daily) for 10 days. Therapeutic efficacy was then evaluated on the basis of changes in clinical status, radiographic findings and, where possible, bacteriological results. Cefadroxil treatment produced a 90% cure rate assessed clinically and by radiological confirmation; moreover, the drug was well tolerated in the majority of patients.