Literature DB >> 3801782

Systemic baclofen stimulates gastric motility and secretion via a central action in the rat.

P L Andrews, K L Wood.   

Abstract

Intravenous (0.5 mg kg-1) or subcutaneous (2-16 mg kg-1) administration of the gamma-aminobutyric acid (GABA) analogue baclofen resulted in a stimulation of gastric motility and secretion in the rat, anaesthetized with urethane. The motility response to subcutaneous injection was dose-related. This effect was abolished by vagotomy or atropine. There was no response to baclofen in decerebrate animals. These results indicate that systemic baclofen, probably acting at a site rostral to the brainstem, stimulates gastric motility and acid secretion by a vagally-dependent mechanism.

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Year:  1986        PMID： 3801782      PMCID： PMC1917152          DOI： 10.1111/j.1476-5381.1986.tb11145.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  20 in total

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  6 in total

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