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Literature DB >> 3801273

Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product.

S Y Chan, G I Evan, A Ritson, J Watson, P Wraight, K Sikora.

Abstract

A set of mouse nonoclonal antibodies against the c-myc oncogene product, a 62,000 dalton nuclear binding protein involved in cell cycle control, has been constructed by immunisation with synthetic peptide fragments. One such antibody, CT14, was radiolabelled with 131I and administered to 20 patients with different malignant diseases. Good tumour localisation was observed in 12 out of 14 patients with primary bronchial carcinoma but not in patients with pulmonary metastases from primary tumours elsewhere. Successfully localised tumours were all 3 cm or more in diameter. Monoclonal antibodies against oncogene products may provide novel selective tools for the diagnosis and therapy of cancer.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3801273 PMCID： PMC2001543 DOI： 10.1038/bjc.1986.238

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

12 in total

Review 1. Cellular transforming genes and oncogenesis.

Authors: G M Cooper; M A Lane
Journal: Biochim Biophys Acta Date: 1984

Review 2. Cancer genes come of age.

Authors: J M Bishop
Journal: Cell Date: 1983-04 Impact factor: 41.582

3. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.

Authors: K Kelly; B H Cochran; C D Stiles; P Leder
Journal: Cell Date: 1983-12 Impact factor: 41.582

4. Spatial and temporal pattern of cellular myc oncogene expression in developing human placenta: implications for embryonic cell proliferation.

Authors: S Pfeifer-Ohlsson; A S Goustin; J Rydnert; T Wahlström; L Bjersing; D Stehelin; R Ohlsson
Journal: Cell Date: 1984-09 Impact factor: 41.582

Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product.

Review 1. Cellular transforming genes and oncogenesis.

Review 2. Cancer genes come of age.

3. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.

4. Spatial and temporal pattern of cellular myc oncogene expression in developing human placenta: implications for embryonic cell proliferation.

5. Amplification and expression of the c-myc oncogene in human lung cancer cell lines.

6. Expression of cellular oncogenes in human malignancies.

Review 7. The emerging genetics of human cancer.

8. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

9. Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle.

10. Localisation of metastatic carcinoma by a radiolabelled monoclonal antibody.

1. c-myc coded oncoprotein for immunotargeting. Oropharyngeal and other tumors at S.N. Medical College, Agra, India.

2. Inhibition of the hepatocyte uptake of radiolabelled monoclonal antibodies by chelating agents.

3. Immunoscintigraphy of human lung squamous cell carcinoma using an iodine-131 labelled monoclonal antibody (Po66).

4. The effect of circulating antigen and radiolabel stability on the biodistribution of an indium labelled antibody.

Review 5. Genes and cancer: a clinical perspective.