Literature DB >> 3801027

Protein kinase C activity in platelets from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY).

K Takaori, S Itoh, Y Kanayama, T Takeda.   

Abstract

Calcium-activated phospholipid dependent protein kinase (protein kinase C) activity in platelets was measured in 4, 12, and 20-week-old SHR and WKY. At age 4-weeks, there was no significant difference in protein kinase C activity and systolic blood pressure between SHR and WKY. In 12 and 20-week-old SHR, both protein kinase C activity and systolic blood pressure were significantly higher than in the age-matched WKY. These results suggest that protein kinase C may be involved in the control of blood pressure in SHR and WKY.

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Year:  1986        PMID: 3801027     DOI: 10.1016/s0006-291x(86)80239-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN: 0006-291X            Impact factor:   3.575


  5 in total

1.  Proceedings of the British Pharmacological Society, Clinical Pharmacology Section. 5-7 April 1989, Bristol. Abstracts.

Authors: 
Journal:  Br J Clin Pharmacol       Date:  1989-08       Impact factor: 4.335

2.  Alterations of phosphoinositide-specific phospholipase C and protein kinase C in the myocardium of spontaneously hypertensive rats.

Authors:  N Makita; H Yasuda
Journal:  Basic Res Cardiol       Date:  1990 Sep-Oct       Impact factor: 17.165

3.  Vasopressin stimulates phospholipase D activity against phosphatidylcholine in vascular smooth muscle cells.

Authors:  C J Welsh; K Schmeichel; H T Cao; H Chabbott
Journal:  Lipids       Date:  1990-11       Impact factor: 1.880

4.  Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidences for receptor regulation.

Authors:  L Larose; J J Rondeau; H Ong; A De Léan
Journal:  Mol Cell Biochem       Date:  1992-10-07       Impact factor: 3.396

Review 5.  Defective phosphoinositide metabolism in primary hypertension.

Authors:  A Remmal; S Koutouzov; A Girard; P Meyer; P Marche
Journal:  Experientia       Date:  1988-02-15
  5 in total

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