Literature DB >> 3801009

Brain-derived growth factor is a chemoattractant for fibroblasts and astroglial cells.

R M Senior, S S Huang, G L Griffin, J S Huang.   

Abstract

Bovine brain-derived growth factor (BDGF), a 16-17 kDa protein with biochemical properties resembling brain-derived acidic fibroblast growth factor (acidic FGF) and endothelial cell growth factor, was found to have potent chemotactic activity for bovine ligament fibroblasts, human skin fibroblasts and rat astroglial cells, maximal at 100-200 pg/ml. The chemotactic activity was completely blocked by protamine sulfate (5 ug/ml), an inhibitor of receptor-binding and mitogenic activity of BDGF. BDGF did not stimulate migration of human monocytes. These results indicate that the effects of BDGF 'in vivo' might extend to mesenchymal cell recruitment.

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Year:  1986        PMID： 3801009     DOI： 10.1016/s0006-291x(86)80335-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo.

Authors:  J A Thompson; C C Haudenschild; K D Anderson; J M DiPietro; W F Anderson; T Maciag
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

2.  PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

Authors:  D G Greenhalgh; K H Sprugel; M J Murray; R Ross
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307

Review 3.  Autocrine regulation of cell growth and transformation by basic fibroblast growth factor.

Authors:  A Yayon; M Klagsbrun
Journal:  Cancer Metastasis Rev       Date:  1990-11       Impact factor: 9.264

4.  Autonomous migration of human fetal skin fibroblasts into a denuded area in a cell monolayer is mediated by basic fibroblast growth factor and collagen.

Authors:  H Kondo; R Matsuda; Y Yonezawa
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-12       Impact factor: 2.416

5.  Fine-Sampled Photographic Quantitation of Dermal Wound Healing Senescence in Aged BALB/cByJ Mice and Therapeutic Intervention with Fibroblast Growth Factor-1.

Authors:  Alana P Mellers; Connie A Tenorio; Diana A Lacatusu; Brett D Powell; Bhavi N Patel; Kathleen M Harper; Michael Blaber
Journal:  Adv Wound Care (New Rochelle)       Date:  2018-12-08       Impact factor: 4.730

6.  A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury.

Authors:  A Logan; S A Frautschy; A M Gonzalez; A Baird
Journal:  J Neurosci       Date:  1992-10       Impact factor: 6.167

7.  Effects of growth factors in vivo. I. Cell ingrowth into porous subcutaneous chambers.

Authors:  K H Sprugel; J M McPherson; A W Clowes; R Ross
Journal:  Am J Pathol       Date:  1987-12       Impact factor: 4.307

8.  Acidic fibroblast growth factor in the developing rat embryo.

Authors:  Y M Fu; P Spirito; Z X Yu; S Biro; J Sasse; J Lei; V J Ferrans; S E Epstein; W Casscells
Journal:  J Cell Biol       Date:  1991-09       Impact factor: 10.539
  8 in total

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