Literature DB >> 3800880

Disulphide reduction in lysosomes. The role of cysteine.

J B Lloyd.   

Abstract

Published evidence indicates that cystine-containing proteins have their disulphide bonds reduced during proteolysis in lysosomes. However, the intralysosomal accumulation of cystine in the cells of patients with cystinosis has been seen as evidence that protein cystine residues are not reduced. The data are reconcilable and fully in harmony if it is postulated that cysteine from the cytoplasm is the physiological reducing agent.

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Year:  1986        PMID： 3800880      PMCID： PMC1146975          DOI： 10.1042/bj2370271

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo.

Authors:  J G Thoene; R G Oshima; J C Crawhall; D L Olson; J A Schneider
Journal:  J Clin Invest       Date:  1976-07       Impact factor: 14.808

2.  Cystinotic fibroblasts accumulate cystine from intracellular protein degradation.

Authors:  J G Thoene; R G Oshima; D G Ritchie; J A Schneider
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

3.  Modulation of the intracellular cystine content of cystinotic fibroblasts by extracellular albumin.

Authors:  J G Thoene; R Lemons
Journal:  Pediatr Res       Date:  1980-06       Impact factor: 3.756

4.  Evidence for lysosomal reduction of cystine residues.

Authors:  P A Griffiths; J B Lloyd
Journal:  Biochem Biophys Res Commun       Date:  1979-07-27       Impact factor: 3.575

5.  Stimulation of intralysosomal proteolysis by cysteinyl-glycine, a product of the action of gamma-glutamyl transpeptidase on glutathione.

Authors:  J L Mego
Journal:  Biochim Biophys Acta       Date:  1985-08-16

6.  Pantetheinase activity and cysteamine content in cystinotic and normal fibroblasts and leukocytes.

Authors:  S Orloff; J D Butler; D Towne; A B Mukherjee; J D Schulman
Journal:  Pediatr Res       Date:  1981-07       Impact factor: 3.756

7.  Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albumin.

Authors:  J L Mego
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

8.  Role of thiols in degradation of proteins by cathepsins.

Authors:  T Kooistra; P C Millard; J B Lloyd
Journal:  Biochem J       Date:  1982-05-15       Impact factor: 3.857

9.  Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine.

Authors:  J G Thoene; R M Lemons
Journal:  Biochem J       Date:  1982-12-15       Impact factor: 3.857

10.  Disulfide spacer between methotrexate and poly(D-lysine). A probe for exploring the reductive process in endocytosis.

Authors:  W C Shen; H J Ryser; L LaManna
Journal:  J Biol Chem       Date:  1985-09-15       Impact factor: 5.157
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  15 in total

1.  Lysosomal handling of cystine residues: stoichiometry of cysteine involvement.

Authors:  J B Lloyd
Journal:  Biochem J       Date:  1992-09-15       Impact factor: 3.857

2.  Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT).

Authors:  B Arunachalam; U T Phan; H J Geuze; P Cresswell
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

Review 3.  Design of smart HPMA copolymer-based nanomedicines.

Authors:  Jiyuan Yang; Jindřich Kopeček
Journal:  J Control Release       Date:  2015-10-03       Impact factor: 9.776

4.  Importance of thioredoxin in the proteolysis of an immunoglobulin G as antigen by lysosomal Cys-proteases.

Authors:  I Kerblat; C Drouet; S Chesne; P N Marche
Journal:  Immunology       Date:  1999-05       Impact factor: 7.397

5.  Glutathione-induced conversion of pentavalent antimony to trivalent antimony in meglumine antimoniate.

Authors:  F Frézard; C Demicheli; C S Ferreira; M A Costa
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

6.  Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells.

Authors:  E Carrasco-Marín; J E Paz-Miguel; P López-Mato; C Alvarez-Domínguez; F Leyva-Cobián
Journal:  Immunology       Date:  1998-11       Impact factor: 7.397

Review 7.  Redox Signaling by Reactive Electrophiles and Oxidants.

Authors:  Saba Parvez; Marcus J C Long; Jesse R Poganik; Yimon Aye
Journal:  Chem Rev       Date:  2018-08-27       Impact factor: 60.622

8.  Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.

Authors:  Virginie Janssens; Héloïse P Gaide Chevronnay; Sandrine Marie; Marie-Françoise Vincent; Patrick Van Der Smissen; Nathalie Nevo; Seppo Vainio; Rikke Nielsen; Erik I Christensen; François Jouret; Corinne Antignac; Christophe E Pierreux; Pierre J Courtoy
Journal:  J Am Soc Nephrol       Date:  2019-09-23       Impact factor: 10.121

9.  Antioxidant effect of cysteamine in brain cortex of young rats.

Authors:  Adriana Kessler; Micheli Biasibetti; Denizar Alberto da Silva Melo; Moacir Wajner; Carlos Severo Dutra-Filho; Angela Terezinha de Souza Wyse; Clovis Milton Duval Wannmacher
Journal:  Neurochem Res       Date:  2007-10-17       Impact factor: 3.996

10.  Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex.

Authors:  Vandré Casagrande Figueiredo; Luciane Rosa Feksa; Clovis Milton Duval Wannmacher
Journal:  Metab Brain Dis       Date:  2009-05-13       Impact factor: 3.584
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