Literature DB >> 3800354

Ketoconazole in experimental vaginal candidosis in rats.

O S Kinsman, A E Collard, T J Savage.   

Abstract

Rats in pseudoestrous were treated subcutaneously with ketoconazole at 25 mg/kg twice a day. In both uninfected and infected rats ketoconazole inhibited the cornification of the vaginal epithelium. Thus, ketoconazole, in addition to having an antifungal effect, may aid in the removal of candida by inhibiting the epithelial conditions suitable for hyphal invasion.

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Year:  1986        PMID： 3800354      PMCID： PMC176530          DOI： 10.1128/AAC.30.5.771

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Ketoconazole and cholesterol synthesis.

Authors:  T A Miettinen; V V Valtonen
Journal:  Lancet       Date:  1984-12-01       Impact factor: 79.321

2.  Hormonal factors in vaginal candidiasis in rats.

Authors:  O S Kinsman; A E Collard
Journal:  Infect Immun       Date:  1986-09       Impact factor: 3.441

3.  Ketoconazole blocks testosterone synthesis.

Authors:  A Pont; P L Williams; S Azhar; R E Reitz; C Bochra; E R Smith; D A Stevens
Journal:  Arch Intern Med       Date:  1982-11

4.  In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis.

Authors:  H Van den Bossche; G Willemsens; W Cools; F Cornelissen; W F Lauwers; J M van Cutsem
Journal:  Antimicrob Agents Chemother       Date:  1980-06       Impact factor: 5.191

5.  Ketoconazole -- a new broad spectrum orally active antimycotic.

Authors:  D Thienpont; J Van Cutsem; F Van Gerven; J Heeres; P A Janssen
Journal:  Experientia       Date:  1979-05-15

6.  Ketoconazole blocks adrenal steroid synthesis.

Authors:  A Pont; P L Williams; D S Loose; D Feldman; R E Reitz; C Bochra; D A Stevens
Journal:  Ann Intern Med       Date:  1982-09       Impact factor: 25.391

7.  In vitro inhibition of testosterone biosynthesis by ketoconazole.

Authors:  S C Sikka; R S Swerdloff; J Rajfer
Journal:  Endocrinology       Date:  1985-05       Impact factor: 4.736

8.  Comparison of ketoconazole, Bay N7133, and Bay L9139 in the treatment of experimental vaginal candidiasis.

Authors:  J D Sobel; G Muller
Journal:  Antimicrob Agents Chemother       Date:  1983-09       Impact factor: 5.191

9.  Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins.

Authors:  D S Grosso; T W Boyden; R W Pamenter; D G Johnson; D A Stevens; J N Galgiani
Journal:  Antimicrob Agents Chemother       Date:  1983-02       Impact factor: 5.191

10.  Influence of estrogen and normal flora on vaginal candidiasis in the rat.

Authors:  B Larsen; R P Galask
Journal:  J Reprod Med       Date:  1984-12       Impact factor: 0.142
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