| Literature DB >> 3799529 |
Y Shiki, Y Ishikawa, K Shirai, Y Saito, S Yoshida.
Abstract
The influence of glycyrrhizin on the effect of phospholipase A2 on lysosomes was studied. Treatment of rat liver lysosomes with venom phospholipase A2 caused release of acid phosphatase. This release of acid phosphatase was inhibited by 0.1 mM glycyrrhizin. Glycyrrhizin also inhibited acid phospholipase A2 with pH optimum of 4.5, which is thought to be present in the lysosomal membrane. These results suggest that glycyrrhizin stabilizes lysosomes by inhibiting phospholipase A2 activity in the lysosomal membrane.Entities:
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Year: 1986 PMID： 3799529 DOI： 10.1142/S0192415X86000211
Source DB: PubMed Journal: Am J Chin Med ISSN： 0192-415X Impact factor: 4.667