| Literature DB >> 3798475 |
K P Rao, S Shaheen, M V Usha Rani, M S Rao.
Abstract
Primidone, an anti-convulsant drug, was tested in mice for mutagenicity in somatic cells by the micronucleus test and in germ cells by the sperm-head abnormality assay. Mice were treated orally with the drug at doses of 4.37, 8.75 and 13.11 mg/mouse. The results indicate that the drug is capable of inducing mutations both in somatic and germ cells of mice.Entities:
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Year: 1986 PMID： 3798475 DOI： 10.1016/0378-4274(86)90204-3
Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372