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Literature DB >> 379676

Effect of barbiturates on release endogenous amino acids from rat cortex slices.

Abstract

The potassium-stimulated, calcium-dependent release of endogenous GABA and glutamic acid was suppressed by pentobarbital. The ouabain and veratridine-stimulated fluxes of the amino acids, calcium-independent processes, were not suppressed by pentobarbital. Release of GABA and glutamic acid was not suppressed by pentobarbital in the presence of the calcium ionophore A23187. Of eight barbiturates studied at equimolar concentrations six were found to inhibit GABA release. Thiopental was the most potent, and phenobarbital and secobarbital were inactive.

Entities: Chemical Species

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Year: 1979 PMID： 379676 DOI： 10.1007/bf00963802

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

22 in total

1. Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons.

Authors: R L Macdonald; J L Barker
Journal: Science Date: 1978-05-19 Impact factor: 47.728

2. Pentobarbital selectively enhances GABA-mediated post-synaptic inhibition in tissue cultured mouse spinal neurons.

Authors: B R Ransom; J L Barker
Journal: Brain Res Date: 1976-09-24 Impact factor: 3.252

3. Effects of acetylcholine on potassium-induced changes of GABA and taurine uptakes and release in cerebral cortex slices from the rat.

Authors: A M Benjamin; J H Quastel
Journal: Can J Physiol Pharmacol Date: 1977-06 Impact factor: 2.273

4. The selective depression of evoked cortical EPSPs by pentobarbitone.

Authors: C D Richards
Journal: J Physiol Date: 1971 Impact factor: 5.182

5. Effect of barbiturates on 'quantal' synaptic transmission in spinal motoneurones.

Authors: J N Weakly
Journal: J Physiol Date: 1969-09 Impact factor: 5.182

6. Sodium ion movements and the spontaneous and electrically stimulated release of ( 3 H)GABA and ( 14 C)glutamic acid from rat cortical slices.

Authors: J P Hammerstad; R W Cutler
Journal: Brain Res Date: 1972-12-12 Impact factor: 3.252

2. A kinetic analysis of the release of acidic amino acids from rat cortical synaptosomes following pre-loading with [14C]glutamic acid.

Authors: D D Wheeler; W C Wise
Journal: Neurochem Res Date: 1983-09 Impact factor: 3.996

3. The effects of anaesthetics on the uptake and release of amino acid neurotransmitters in thalamic slices.

Authors: T J Kendall; M C Minchin
Journal: Br J Pharmacol Date: 1982-01 Impact factor: 8.739

4. Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro.

Authors: S Zeman; D Lodge
Journal: Br J Pharmacol Date: 1992-06 Impact factor: 8.739

5. The effect of anaesthetics on the uptake and release of gamma-aminobutyrate and D-aspartate in rat brain slices.

Authors: M C Minchin
Journal: Br J Pharmacol Date: 1981-07 Impact factor: 8.739

5 in total

Effect of barbiturates on release endogenous amino acids from rat cortex slices.

1. Different actions of anticonvulsant and anesthetic barbiturates revealed by use of cultured mammalian neurons.

2. Pentobarbital selectively enhances GABA-mediated post-synaptic inhibition in tissue cultured mouse spinal neurons.

3. Effects of acetylcholine on potassium-induced changes of GABA and taurine uptakes and release in cerebral cortex slices from the rat.

4. The selective depression of evoked cortical EPSPs by pentobarbitone.

5. Effect of barbiturates on 'quantal' synaptic transmission in spinal motoneurones.

6. Sodium ion movements and the spontaneous and electrically stimulated release of ( 3 H)GABA and ( 14 C)glutamic acid from rat cortical slices.

7. Effects of anesthetics on sodium uptake into rat brain cortex in vitro.

8. Regional changes in amino acid content in developing rat brain.

9. The effects of anaesthetics on synaptic excitation and inhibition in the olfactory bulb.

10. Release and exchange of neurotransmitters in synaptosomes: Effects of the ionophore A23187 and of ouabain.

1. Depolarization-induced release of amino acids from the vestibular nuclear complex.

2. A kinetic analysis of the release of acidic amino acids from rat cortical synaptosomes following pre-loading with [14C]glutamic acid.

3. The effects of anaesthetics on the uptake and release of amino acid neurotransmitters in thalamic slices.

4. Pharmacological characterization of non-NMDA subtypes of glutamate receptor in the neonatal rat hemisected spinal cord in vitro.

5. The effect of anaesthetics on the uptake and release of gamma-aminobutyrate and D-aspartate in rat brain slices.