Literature DB >> 379630

Antioxidants reduce the mutagenic effect of malonaldehyde and beta-propiolactone. Part IX. Antioxidants and cancer.

R J Shamberger, C L Corlett, K D Beaman, B L Kasten.   

Abstract

Increasing concentrations of malonaldehyde and beta-propiolactone were increasingly mutagenic with 7 mutants of Salmonella typhimurium, 5 of which mutated bya frameshift mechanism and 2 of which mutated through base-pair substitution. The antioxidants vitamin C, vitamin E, selenium and butylated hydroxytoluene (BHT) at 3 logarithmic concentrations markedly reduced mutagenesis in those strains which mutated by frameshift mechanism.

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Year:  1979        PMID: 379630     DOI: 10.1016/0165-1218(79)90045-4

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  14 in total

Review 1.  Mineral insufficiency and cancer.

Authors:  A T Diplock
Journal:  Med Oncol Tumor Pharmacother       Date:  1990

2.  Evidence for the antimutagenicity and the mutagenicity of selenium.

Authors:  R J Shamberger
Journal:  Biol Trace Elem Res       Date:  1980-03       Impact factor: 3.738

3.  Formation of formaldehyde and malonaldehyde by photooxidation of squalene.

Authors:  H C Yeo; T Shibamoto
Journal:  Lipids       Date:  1992-01       Impact factor: 1.880

4.  Effect of phenolic antioxidants on the mutagenicity of aflatoxin B1.

Authors:  L A Shelef; B Chin
Journal:  Appl Environ Microbiol       Date:  1980-12       Impact factor: 4.792

5.  Analysis of free malondialdehyde in photoirradiated corn oil and beef fat via a pyrazole derivative.

Authors:  K Umano; K J Dennis; T Shibamoto
Journal:  Lipids       Date:  1988-08       Impact factor: 1.880

Review 6.  How 'safe' are antioxidant vitamins?

Authors:  H S Garewal; A T Diplock
Journal:  Drug Saf       Date:  1995-07       Impact factor: 5.606

7.  Effects of antioxidants on oxidant-induced sister chromatid exchange formation.

Authors:  A B Weitberg; S A Weitzman; E P Clark; T P Stossel
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

8.  Metabolism of malonaldehyde in vivo and in vitro.

Authors:  G M Siu; H H Draper
Journal:  Lipids       Date:  1982-05       Impact factor: 1.880

9.  The antimutagenic effect of selenium on 7,12-dimethylbenz(a)anthracene and metabolites in the amesSalmonella/microsome system.

Authors:  L K Arciszewska; S E Martin; J A Milner
Journal:  Biol Trace Elem Res       Date:  1982-12       Impact factor: 3.738

10.  Iron-induced DNA damage and synthesis in isolated rat liver nuclei.

Authors:  T K Shires
Journal:  Biochem J       Date:  1982-08-01       Impact factor: 3.857

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