Literature DB >> 3795634

A simple and rapid in vitro test for determining sensitivity of cancer cells to anticancer drugs.

H Ichihashi, M Nogaki, M Yamauchi, H Takagi, T Kondo, T Ozawa.   

Abstract

For practical utilization of chemosensitivity tests of malignant cells to anticancer drugs in clinical studies, we developed a new method which is simple, rapid, and applicable to fresh human tumors. The principle of the method is to measure the content of ATP of living cells by chemoluminescence, after drug exposure. A straight linear relationship was observed between the number of viable cells and the light intensity. This method seems to be a good indicator for the selection of anticancer drugs in cancer chemotherapy.

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Year:  1986        PMID： 3795634     DOI： 10.1007/bf02470564

Source DB:  PubMed          Journal:  Jpn J Surg        ISSN： 0047-1909


  12 in total

1.  Firefly luminescence in the study of energy transfer mechanisms. I. Substrate and enzyme determination.

Authors:  B L STREHLER; J R TOTTER
Journal:  Arch Biochem Biophys       Date:  1952-09       Impact factor: 4.013

2.  Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. III. The growth fraction.

Authors:  M L MENDELSOHN
Journal:  J Natl Cancer Inst       Date:  1962-05       Impact factor: 13.506

3.  A Comparison of the Growth Curves of Malignant and Normal (Embryonic and Postembryonic) Tissues of the Rat.

Authors:  R Schrek
Journal:  Am J Pathol       Date:  1936-07       Impact factor: 4.307

4.  In vitro test for sensitivity of tumor to carcinostatic agents.

Authors:  T Kondo; T Imamura; H Ichihashi
Journal:  Gan       Date:  1966-04

5.  In vitro soft agar assay by use of multiple for screening of tumor sensitivity to anticancer drugs.

Authors:  H Ichihashi; T Sakoh; T Kondo
Journal:  Jpn J Surg       Date:  1983-11

6.  In vitro effects on DNA synthesis as a predictor of biological effect from chemotherapy.

Authors:  R B Livingston; G A Titus; L K Heilbrun
Journal:  Cancer Res       Date:  1980-07       Impact factor: 12.701

7.  Predication of the effect of carcinostatic agents on tumor-bearing host by the sensitivity test using acid phosphatase activity in vitro.

Authors:  T Kondo; H Ichihashi; M Imaizumi
Journal:  Gan       Date:  1976-10

8.  Relationship between regional myocardial blood flow and tissue ATP content in acute ischemia.

Authors:  K Itoh; T Matsubara; M Nanki; K Nishimura; T Kambe; S Sugiyama; T Ozawa; N Sakamoto
Journal:  Jpn Heart J       Date:  1984-07

9.  Evaluation of inhibition of human tumor tissue by cancer chemotherapeutic drugs with an in vitro test.

Authors:  J A DIPAOLO; J E DOWD
Journal:  J Natl Cancer Inst       Date:  1961-10       Impact factor: 13.506

10.  Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs.

Authors:  S E Salmon; A W Hamburger; B Soehnlen; B G Durie; D S Alberts; T E Moon
Journal:  N Engl J Med       Date:  1978-06-15       Impact factor: 91.245
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  2 in total

1.  In vitro evaluation of a novel chemotherapeutic agent, Adozelesin, in gynecologic-cancer cell lines.

Authors:  H N Nguyen; B U Sevin; H Averette; J Perras; R Hightower; R Ramos; D Donato; M Penalver
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

2.  Clinical usefulness of an ATP heat sensitivity test using endoscopic biopsy materials from esophageal cancer patients.

Authors:  T Hirai; T Iwata; N Hirabayashi; Y Yamashita; A Yoshimoto; K Noma; T Toge
Journal:  Surg Today       Date:  1995       Impact factor: 2.549
  2 in total

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