Literature DB >> 3794738

Oligoclonal "fingerprint" of CSF IgG in multiple sclerosis patients is not modified following intrathecal administration of natural beta-interferon.

C Confavreux, C Chapuis-Cellier, P Arnaud, O Robert, G Aimard, M Devic.   

Abstract

The IgG pattern in CSF was studied in 11 patients with multiple sclerosis who exhibited an oligoclonal banding upon thin-layer polyacrylamide gel isoelectric focusing followed by silver stain of unconcentrated CSF. Each patient received beta-interferon intrathecally during a 2 month period. No modification was observed over a 6 month period. In addition, the oligoclonal pattern was remarkably unique for each individual representing a typical "fingerprint" which allowed the identification of any single CSF.

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Year:  1986        PMID： 3794738      PMCID： PMC1029083          DOI： 10.1136/jnnp.49.11.1308

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  15 in total

1.  Huntington disease: clinical care and evaluation.

Authors:  I Shoulson; S Fahn
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2.  Immunoglobulin G and low molecular weight proteins in human cerebrospinal fluid. Chemical and immunological characterisation with special reference to multiple sclerosis.

Authors:  H Link
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3.  Intrathecal IgG synthesis in multiple sclerosis: comparison between isoelectric focusing and quantitative estimation of cerebrospinal fluid IgG.

Authors:  P Livrea; M Trojano; I L Simone; G B Zimatore; G Lamontanara; R Leante
Journal:  J Neurol       Date:  1981       Impact factor: 4.849

4.  CSF protein examinations with thin-layer isoelectric focusing in multiple sclerosis.

Authors:  A Sidén; K G Kjellin
Journal:  J Neurol Sci       Date:  1978-11       Impact factor: 3.181

Review 5.  Laboratory diagnosis of multiple sclerosis: immunological and biochemical aspects.

Authors:  E J Thompson
Journal:  Br Med Bull       Date:  1977-01       Impact factor: 4.291

6.  Optic neuritis: studies on the cerebrospinal fluid in relation to clinical course in 61 patients.

Authors:  M Sandberg-Wollheim
Journal:  Acta Neurol Scand       Date:  1975-09       Impact factor: 3.209

7.  Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients.

Authors:  C Confavreux; G Aimard; M Devic
Journal:  Brain       Date:  1980-06       Impact factor: 13.501

8.  Biochemical findings in multiple sclerosis IV. Isoelectric focusing of the CSF gamma globulins in multiple sclerosis (262 cases) and other neurological diseases (272 cases).

Authors:  P Delmotte; R Gonsette
Journal:  J Neurol       Date:  1977-04-28       Impact factor: 4.849

9.  Oligoclonal bands in multiple sclerosis: clinical-pathologic correlation.

Authors:  M A Farrell; J C Kaufmann; J J Gilbert; J H Noseworthy; H A Armstrong; G C Ebers
Journal:  Neurology       Date:  1985-02       Impact factor: 9.910

10.  The use and abuse of the cerebrospinal fluid IgG profile in the adult: a practical evaluation.

Authors:  L A Hershey; J L Trotter
Journal:  Ann Neurol       Date:  1980-10       Impact factor: 10.422
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2.  Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis.

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Review 4.  B-cell Therapy for Multiple Sclerosis: Entering an era.

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Review 5.  Intrathecal IgG synthesis: a resistant and valuable target for future multiple sclerosis treatments.

Authors:  Mickael Bonnan
Journal:  Mult Scler Int       Date:  2015-01-08

6.  BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset.

Authors:  M Puthenparampil; L Federle; S Miante; A Zito; E Toffanin; S Ruggero; M Ermani; S Pravato; D Poggiali; P Perini; F Rinaldi; P Gallo
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  6 in total

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