Effect of exercise training on resting blood pressure and heart rate in adult and aged rats.

To test the hypothesis that advancing age may have an effect on cardiovascular adaptation (resting blood pressure and heart rate) in response to exercise training, we compared adult (4.5 months at start of training) and aged (21.5 months at start of training) male Fischer 344 rats exercised on a rodent treadmill 5 days/week for 9 weeks. Two additional age-matched control groups were similarly handled and placed on the nonmoving treadmill for the same duration. Chronic exercise did not alter blood pressure in the adult group but lowered resting blood pressure in the aged rats during the midportion of the training period. On the other hand, the adult group demonstrated a significant decrease in the resting heart rate from Weeks 3 through 7 during training, whereas the aged group showed no change in resting heart rate during the entire study. These findings suggest that there may exist an age-related difference in the effect of exercise training on basal cardiovascular homeostasis, which is cardioinhibitory in the adult and vasodepressant in the aged.