Literature DB >> 3793621

Azinomycins A and B, new antitumor antibiotics. I. Producing organism, fermentation, isolation, and characterization.

K Nagaoka, M Matsumoto, J Oono, K Yokoi, S Ishizeki, T Nakashima.   

Abstract

A strain of Streptomyces griseofuscus S42227 (FERM P-8443) was found to produce new antitumor antibiotics, called azinomycins A and B. The molecular formulas of azinomycins A and B were determined as C30H33N3O10 and C31H33N3O11, respectively. They were active against Gram-positive bacteria, Gram-negative bacteria and L5178Y cells in tissue culture.

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Year:  1986        PMID： 3793621     DOI： 10.7164/antibiotics.39.1527

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Sequence selectivity of azinomycin B in DNA alkylation and cross-linking: a QM/MM study.

Authors:  Dhurairajan Senthilnathan; Anbarasan Kalaiselvan; Ponnambalam Venuvanalingam
Journal:  J Mol Model       Date:  2012-08-24       Impact factor: 1.810

Review 2.  Natural products from thioester reductase containing biosynthetic pathways.

Authors:  Michael W Mullowney; Ryan A McClure; Matthew T Robey; Neil L Kelleher; Regan J Thomson
Journal:  Nat Prod Rep       Date:  2018-09-19       Impact factor: 13.423

3.  Structure of a DNA glycosylase that unhooks interstrand cross-links.

Authors:  Elwood A Mullins; Garrett M Warren; Noah P Bradley; Brandt F Eichman
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-10       Impact factor: 11.205

4.  Biosynthetic studies of aziridine formation in azicemicins.

Authors:  Yasushi Ogasawara; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2009-12-23       Impact factor: 15.419

Review 5.  Dimeric approaches to anti-cancer chemotherapeutics.

Authors:  M K Hadden; B S J Blagg
Journal:  Anticancer Agents Med Chem       Date:  2008-10       Impact factor: 2.505

6.  N,N-DIIsopropyl-N-phosphonyl imines lead to efficient asymmetric synthesis of aziridine-2-carboxylic esters.

Authors:  Padmanabha V Kattamuri; Yiwen Xiong; Yi Pan; Guigen Li
Journal:  Org Biomol Chem       Date:  2013-05-28       Impact factor: 3.876

7.  Mitomycins syntheses: a recent update.

Authors:  Jean-Christophe Andrez
Journal:  Beilstein J Org Chem       Date:  2009-07-08       Impact factor: 2.883

8.  Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage.

Authors:  Shan Wang; Kai Liu; Le Xiao; LiYuan Yang; Hong Li; FeiXue Zhang; Lei Lei; ShengQing Li; Xu Feng; AiYing Li; Jing He
Journal:  Nucleic Acids Res       Date:  2015-09-22       Impact factor: 16.971

9.  Characterization and engineering of Streptomyces griseofuscus DSM 40191 as a potential host for heterologous expression of biosynthetic gene clusters.

Authors:  Tetiana Gren; Christopher M Whitford; Omkar S Mohite; Tue S Jørgensen; Eftychia E Kontou; Julie B Nielsen; Sang Yup Lee; Tilmann Weber
Journal:  Sci Rep       Date:  2021-09-15       Impact factor: 4.379
  9 in total

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