Literature DB >> 3792366

Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma.

P S Conti, P P Sordillo, B Schmall, R S Benua, J R Bading, R E Bigler, J S Laughlin.   

Abstract

A 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 (11C) labeled alpha-aminoisobutyric acid (AIB), a synthetic, non-metabolized amino acid transported into viable cells by the A-type, or alanine-preferring, amino acid transport system. Tumor located in the hilum of the lung was well visualized with 11C-AIB prior to chemotherapy. A gallium image with liver subtraction using 99mTc-sulfur colloid demonstrated regions of increased activity in liver which correlated with regions of increased activity on the 11C-AIB liver image.

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Year:  1986        PMID： 3792366     DOI： 10.1007/bf00263819

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  16 in total

1.  Some aspects of nitrogen and energy metabolism in cancerous subjects: a review.

Authors:  G B MIDER
Journal:  Cancer Res       Date:  1951-11       Impact factor: 12.701

Review 2.  Transport alterations in virus-transformed cells.

Authors:  J R Parnes; K J Isselbacher
Journal:  Prog Exp Tumor Res       Date:  1978

3.  Distinct patterns of entry of two non-metabolizable amino acids into brain and other organs of infant guinea pigs.

Authors:  R J Schain; K S Watanabe
Journal:  J Neurochem       Date:  1972-10       Impact factor: 5.372

Review 4.  Amino acid transport in tumor cells.

Authors:  R M Johnstone; P G Scholefield
Journal:  Adv Cancer Res       Date:  1965       Impact factor: 6.242

5.  Imaging of primary Ewing sarcoma with 13N-L-glutamate.

Authors:  R E Reiman; G Rosen; A S Gelbard; R S Benua; J S Laughlin
Journal:  Radiology       Date:  1982-02       Impact factor: 11.105

6.  Tumor localization of alpha-aminoisobutyric acid (AIB) in human melanoma heterotransplants.

Authors:  P S Conti; E M Sordillo; P P Sordillo; B Schmall
Journal:  Eur J Nucl Med       Date:  1985

7.  Evaluation of [1-11C]-alpha-aminoisobutyric acid for tumor detection and amino acid transport measurement: spontaneous canine tumor studies.

Authors:  R E Bigler; P B Zanzonico; B Schmall; P S Conti; J R Dahl; L Rothman; G Sgouros; E G MacEwen
Journal:  Eur J Nucl Med       Date:  1985

8.  Synthesis and quality assurance of [11C]alpha-aminoisobutyric acid (AIB), a potential radiotracer for imaging and amino acid transport studies in normal and malignant tissues.

Authors:  B Schmall; P S Conti; R E Bigler; P B Zanzonico; J R Dahl; B M Sundoro-Wu; J K Jacobsen; R Lee
Journal:  Int J Nucl Med Biol       Date:  1984

Review 9.  Tumor detection with radiopharmaceuticals.

Authors:  S Packer
Journal:  Semin Nucl Med       Date:  1984-01       Impact factor: 4.446

10.  Imaging of the human heart after administration of L-(N-13)glutamate.

Authors:  A S Gelbard; R S Benua; R E Reiman; J M McDonald; J J Vomero; J S Laughlin
Journal:  J Nucl Med       Date:  1980-10       Impact factor: 10.057
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