Literature DB >> 3791720

No effect of acetylcystein on refractory rheumatoid arthritis.

H Jonsson, F A Wollheim, B Svensson.   

Abstract

Acetylcystein has some chemical similarities with Penicillamine and other thiol containing compounds with effect on rheumatoid arthritis. We report an open trial on seven patients with refractory rheumatoid arthritis in which no beneficial effect could be seen after up to twelve months treatment in doses 600-1200 mg acetylcystein daily. No definite laboratory changes were seen, apart from a tendency towards higher IgA levels at the end of the treatment period.

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Year:  1986        PMID： 3791720

Source DB:  PubMed          Journal:  Clin Exp Rheumatol        ISSN： 0392-856X            Impact factor:   4.473


  3 in total

1.  Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a randomized double-blind placebo-controlled trial.

Authors:  Kamal Esalatmanesh; Alireza Jamali; Roozbeh Esalatmanesh; Zahra Soleimani; Alireza Khabbazi; Aida Malek Mahdavi
Journal:  Amino Acids       Date:  2022-02-08       Impact factor: 3.520

Review 2.  N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.

Authors:  Dimitrios Tsikas; Marie Mikuteit
Journal:  Amino Acids       Date:  2022-07-13       Impact factor: 3.789

3.  Efficacy of Mitochondrial Antioxidant Plastoquinonyl-decyl-triphenylphosphonium Bromide (SkQ1) in the Rat Model of Autoimmune Arthritis.

Authors:  Alexander A Andreev-Andrievskiy; Nataliya G Kolosova; Natalia A Stefanova; Maxim V Lovat; Maxim V Egorov; Vasily N Manskikh; Roman A Zinovkin; Ivan I Galkin; Anastasia S Prikhodko; Maxim V Skulachev; Alexander N Lukashev
Journal:  Oxid Med Cell Longev       Date:  2016-05-18       Impact factor: 6.543
  3 in total

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