Molecular biology of myocardial proteins.

There are many possible applications of molecular biology to cardiovascular research. Specific examples discussed in this article include the following: Molecular diversity of ventricular myosin. Myosin heavy chain (HC) structure can be described both at the protein and cDNA levels. Change in the expression of myosin genes. Transitions in the myosin HCs during normal development and after experimental manipulation of the heart can be obtained. Control of gene transcription. There have been recent studies of total mRNA and myosin HC-specific mRNAs using techniques of molecular biology. Structure of the myosin HC gene.