Literature DB >> 3791349

Influence of oxygen radicals generated by xanthine oxidase in the isolated perfused rat heart.

K Ytrehus, R Myklebust, O D Mjøs.   

Abstract

To investigate the cardiac effects of enzymatically generated oxygen radicals isolated Langendorff rat heart preparations were perfused with hypoxanthine (0.96 mmol X litre-1) plus xanthine oxidase (0.025 U X ml-1). Oxygen radicals produced an immediate increase in coronary flow. After 10 min a pronounced reduction in contractile performance, as well as in concentrations of high energy phosphates, was seen. Electron microscopical examination showed damage with cellular oedema as a prominent finding. These effects were all effectively reversed by the specific enzymes, superoxide dismutase and catalase, proving that they were due to oxygen radicals.

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Year:  1986        PMID： 3791349     DOI： 10.1093/cvr/20.8.597

Source DB:  PubMed          Journal:  Cardiovasc Res        ISSN： 0008-6363            Impact factor:   10.787


  17 in total

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Review 9.  The effect of oxidants on biomembranes and cellular metabolism.

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