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Literature DB >> 3791304

Tumor therapy of neoplastic diseases with tumor cells and neuraminidase. Further experimental studies on chessboard vaccination in canine mammary tumors.

Abstract

The therapeutic effect of i.d. injection of tumor cells mixed with Vibrio cholerae neuraminidase (VCN) on tumor progression in dogs with spontaneous mammary tumors was investigated. The i.d. injections were performed in a chessboard-like manner: different numbers (10(5), 10(6), 10(7), and 10(8) of mitomycin-treated autologous tumor cells (M-TC) were each mixed with different amounts (10, 50, and 100 mU) of VCN. These different mixtures were injected i.d. at different sites in dogs on the day of resection of a part of multiple tumors.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 3791304 DOI： 10.1007/bf00205649

Source DB: PubMed Journal: Cancer Immunol Immunother ISSN： 0340-7004 Impact factor: 6.968

53 in total

1. The cytotoxic reactivity and sialic acid content of human lymphoid cells.

Authors: E G Reisner; M W Flye; K S Chung; D B Amos
Journal: Tissue Antigens Date: 1974

2. In vitro immune stimulation-inhibition to spontaneous canine tumors of various histologic types.

Authors: I J Fidler; R S Brodey; S Bech-Nielsen
Journal: J Immunol Date: 1974-03 Impact factor: 5.422

3. Active specific immunotherapy of minimal residual tumor: excision plus neuraminidase-treated tumor cells.

Authors: A Rios; R L Simmons
Journal: Int J Cancer Date: 1974-01-15 Impact factor: 7.396

4. Effect of neuraminidase on growth of a 3-methylcholanthrene-induced fibrosarcoma in normal and immunosuppressed syngeneic mice.

Authors: R L Simmons; A Rios; P K Ray; G Lundgren
Journal: J Natl Cancer Inst Date: 1971-11 Impact factor: 13.506

5. Antigenic enhancement of canine mammary tumours by autoimmunisation with DNP-conjugates.

Authors: D Hannant; R W Else; G W Crighton
Journal: Vet Rec Date: 1979-04-14 Impact factor: 2.695

6. BCG sensitization of guinea-pigs--an animal model for demonstrating the immuno-stimulating effects of various substances.

Authors: H Ronneberger; R Johannsen
Journal: Int J Immunopharmacol Date: 1979

Tumor therapy of neoplastic diseases with tumor cells and neuraminidase. Further experimental studies on chessboard vaccination in canine mammary tumors.

1. The cytotoxic reactivity and sialic acid content of human lymphoid cells.

2. In vitro immune stimulation-inhibition to spontaneous canine tumors of various histologic types.

3. Active specific immunotherapy of minimal residual tumor: excision plus neuraminidase-treated tumor cells.

4. Effect of neuraminidase on growth of a 3-methylcholanthrene-induced fibrosarcoma in normal and immunosuppressed syngeneic mice.

5. Antigenic enhancement of canine mammary tumours by autoimmunisation with DNP-conjugates.

6. BCG sensitization of guinea-pigs--an animal model for demonstrating the immuno-stimulating effects of various substances.

Review 7. Laboratory tests for diagnosis of autoimmune diseases.

8. "Unmasking" of human lymphoid cell heteroantigens by neuraminidase treatment.

9. Antigens associated with canine spontaneous mammary carcinoma.

10. Neuraminidase and tumor immunotherapy.

Review 1. Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment.

2. Enhancing CAR T function with the engineered secretion of C. perfringens neuraminidase.