| Literature DB >> 3790571 |
R B Guyer, J M Nonnemaker, R A Deering.
Abstract
We have isolated and partially characterized a uracil-DNA glycosylase activity from the cellular slime mold, Dictyostelium discoideum. This glycosylase has a broad pH optimum (6.5-8.5) and is fully active in 10 mM EDTA or in 5 mM Mg2+. Its molecular weight by gel filtration is about 55 000. This enzyme activity may work in concert with previously described apurinic/apyrimidinic (AP) endonuclease activities in the excision repair of uracil from the DNA of this lower eukaryote.Entities:
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Year: 1986 PMID： 3790571 DOI： 10.1016/0167-4781(86)90063-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002