Literature DB >> 3790421

Ocular toxicity following ethambutol in standard dosage.

V K Chatterjee, D R Buchanan, A I Friedmann, M Green.   

Abstract

We describe a patient who developed rapid irreversible blindness following treatment with ethambutol in the recommended dose of 15 mg/kg body weight which in clinical practice is widely considered to be safe. This case exemplifies the potential risks of ethambutol and re-emphasizes the importance of instructing patients to stop the drug at once if they develop visual symptoms.

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Year:  1986        PMID: 3790421     DOI: 10.1016/0007-0971(86)90066-5

Source DB:  PubMed          Journal:  Br J Dis Chest        ISSN: 0007-0971


  13 in total

Review 1.  Ethambutol in tuberculosis: time to reconsider?

Authors:  S M Graham; H M Daley; A Banerjee; F M Salaniponi; A D Harries
Journal:  Arch Dis Child       Date:  1998-09       Impact factor: 3.791

2.  Decreased retinal nerve fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy.

Authors:  Samantha J Chai; Rod Foroozan
Journal:  Br J Ophthalmol       Date:  2007-01-10       Impact factor: 4.638

3.  Ocular toxicity from ethambutol.

Authors:  K M Citron; G O Thomas
Journal:  Thorax       Date:  1986-10       Impact factor: 9.139

4.  Exploration of the Plausible Mechanism of Ethambutol Induced Ocular Toxicity by Using Proteomics Informed Physiologically Based Pharmacokinetic (PBPK) Modeling.

Authors:  Ankit Balhara; Mayur K Ladumor; Rakesh P Nankar; Samiulla Dodheri Syed; Sanjeev Giri; Bhagwat Prasad; Saranjit Singh
Journal:  Pharm Res       Date:  2022-03-17       Impact factor: 4.200

Review 5.  Drug-induced ocular disorders.

Authors:  Junping Li; Ramesh C Tripathi; Brenda J Tripathi
Journal:  Drug Saf       Date:  2008       Impact factor: 5.606

6.  Toxic ocular effects of ethambutol.

Authors:  L M Kahana
Journal:  CMAJ       Date:  1987-08-01       Impact factor: 8.262

Review 7.  Clinically important ocular reactions to systemic drug therapy.

Authors:  I G Rennie
Journal:  Drug Saf       Date:  1993-09       Impact factor: 5.606

Review 8.  Avoidance and management of adverse reactions to antituberculosis drugs.

Authors:  A M Patel; J McKeon
Journal:  Drug Saf       Date:  1995-01       Impact factor: 5.606

9.  Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS).

Authors:  Shawn T Phillips; James N Dodds; Jody C May; John A McLean
Journal:  Methods Mol Biol       Date:  2019

10.  Determination of potential role of antioxidative status and circulating biochemical markers in the pathogenesis of ethambutol induced toxic optic neuropathy among diabetic and non-diabetic patients.

Authors:  Mahmood Rasool; Arif Malik; Abdul Manan; Khuram Aziz; Amna Mahmood; Saima Zaheer; Naveed Shuja; Mahmood Husain Qazi; Mohammad Amjad Kamal; Sajjad Karim
Journal:  Saudi J Biol Sci       Date:  2014-10-12       Impact factor: 4.219

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