Literature DB >> 3789049

Influence of HLA-DR phenotype and myopia on the risk of nonproliferative and proliferative diabetic retinopathy.

R S Baker, L I Rand, A S Krolewski, T Maki, J H Warram, L M Aiello.   

Abstract

The relationship between HLA-DR phenotype, refractive error, and risk of both nonproliferative and proliferative diabetic retinopathy was studied among 227 insulin-dependent diabetics participating in a case-control study of diabetic retinopathy. In the absence of myopia, risk of both proliferative and nonproliferative diabetic retinopathy was increased for HLA-DR phenotypes 4/0, 3/0, and X/X (HLA susceptible) compared to HLA-DR phenotypes 3/4, 3/X, and 4/X (HLA nonsusceptible). Odds ratios equalled 11.8 and 7.4 respectively. In the presence of myopia this increased risk associated with HLA status was abolished. Myopia decreased the risk of proliferative and nonproliferative diabetic retinopathy among HLA-susceptible individuals, odds ratio equalled .09 and .09, but had no protective influence among HLA-nonsusceptible individuals.

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Year:  1986        PMID： 3789049     DOI： 10.1016/0002-9394(86)90395-8

Source DB:  PubMed          Journal:  Am J Ophthalmol        ISSN： 0002-9394            Impact factor:   5.258


  5 in total

1.  Coagulation pathways and diabetic retinopathy: abnormal modulation in a selected group of insulin dependent diabetic patients.

Authors:  C Giusti; R Schiaffini; C Brufani; A Pantaleo; E M Vingolo; P Gargiulo
Journal:  Br J Ophthalmol       Date:  2000-06       Impact factor: 4.638

2.  Evidence for control of tumour necrosis factor-alpha (TNF-alpha) activity by TNF receptors in patients with proliferative diabetic retinopathy.

Authors:  G A Limb; H Soomro; S Janikoun; R D Hollifield; J Shilling
Journal:  Clin Exp Immunol       Date:  1999-03       Impact factor: 4.330

3.  Genetic risk factors in diabetic retinopathy.

Authors:  L L Stewart; L L Field; S Ross; R G McArthur
Journal:  Diabetologia       Date:  1993-12       Impact factor: 10.122

4.  Refractive Error and Retinopathy Outcomes in Type 1 Diabetes: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study.

Authors:  Dean P Hainsworth; Xiaoyu Gao; Ionut Bebu; Arup Das; Lisa Olmos de Koo; Andrew J Barkmeier; William Tamborlane; John M Lachin; Lloyd Paul Aiello
Journal:  Ophthalmology       Date:  2020-09-14       Impact factor: 12.079

5.  HLA genes, islet autoantibodies and residual C-peptide at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later.

Authors:  Richard A Jensen; Elisabet Agardh; Ake Lernmark; Soffia Gudbjörnsdottir; Nicholas L Smith; David S Siscovick; Carina Törn
Journal:  PLoS One       Date:  2011-03-11       Impact factor: 3.240
  5 in total

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