Literature DB >> 3788892

Cocaine abuse among opioid addicts: demographic and diagnostic factors in treatment.

T R Kosten, F H Gawin, B J Rounsaville, H D Kleber.   

Abstract

Cocaine is becoming a major drug of abuse among the general population and among opiate addicts. Reports from the early 1970s found that most abusers were older Black males with some antisocial characteristics. Cocaine abuse at that time was reported by about 17% of opiate addicts seeking treatment and by 7 to 11% of ex-addicts on methadone maintenance. However, that rate increased dramatically during the 1970s, and in our 1980 study of 533 addicts we found that 74% of opiate addicts applying for treatment used cocaine. It was the second most abused nonopioid drug after marijuana, surpassing alcohol intoxication. Although the mean number of days of abuse over the previous 30 days was substantially lower among the addicts on our methadone maintenance program (mean = 1.4 days, n = 120) than among the addicts applying for treatment (mean = 9 days, n = 204), the following associations with cocaine abuse were consistent in both subsamples. Cocaine abuse was more frequent among Blacks. It was associated with a variety of antisocial indices including Research Diagnostic Criteria antisocial personality disorder, number of arrests, and legal, family, employment, and drug abuse problems as assessed by the Addiction Severity Index and the Social Adjustment Scale. Several differences emerged between Black and White cocaine-abusing addicts, the most interesting being an increased rate of anxiety disorders among White cocaine abusers. Based on these associations, we offer several guidelines for treating cocaine abuse in opiate addicts.

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Year:  1986        PMID: 3788892     DOI: 10.3109/00952998609083739

Source DB:  PubMed          Journal:  Am J Drug Alcohol Abuse        ISSN: 0095-2990            Impact factor:   3.829


  21 in total

1.  Prevalence of mood and substance use disorders among patients seeking primary care office-based buprenorphine/naloxone treatment.

Authors:  Jonathan D Savant; Declan T Barry; Christopher J Cutter; Michelle T Joy; An Dinh; Richard S Schottenfeld; David A Fiellin
Journal:  Drug Alcohol Depend       Date:  2012-07-06       Impact factor: 4.492

2.  Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice.

Authors:  Jian-Hui Liang; Keng Wang; Hong-Lei Sun; Rong Han
Journal:  Psychopharmacology (Berl)       Date:  2006-01-24       Impact factor: 4.530

3.  Discrete-trials heroin self-administration produces sensitization to the reinforcing effects of cocaine in rats.

Authors:  Sara J Ward; Christopher Läck; Drake Morgan; David C S Roberts
Journal:  Psychopharmacology (Berl)       Date:  2006-01-14       Impact factor: 4.530

4.  Self-administered heroin and cocaine combinations in the rat: additive reinforcing effects-supra-additive effects on nucleus accumbens extracellular dopamine.

Authors:  James E Smith; Conchita Co; Michael D Coller; Scott E Hemby; Thomas J Martin
Journal:  Neuropsychopharmacology       Date:  2006-01       Impact factor: 7.853

5.  Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression.

Authors:  Francesco Leri; Yan Zhou; Brendan Carmichael; Erin Cummins; Mary Jeanne Kreek
Journal:  Eur Neuropsychopharmacol       Date:  2011-07-13       Impact factor: 4.600

6.  Stress and Rodent Models of Drug Addiction: Role of VTA-Accumbens-PFC-Amygdala Circuit.

Authors:  Jasmine J Yap; Klaus A Miczek
Journal:  Drug Discov Today Dis Models       Date:  2008

7.  Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain.

Authors:  Francesco Leri; Yan Zhou; Benjamin Goddard; AnneMarie Levy; Derek Jacklin; Mary Jeanne Kreek
Journal:  Eur Neuropsychopharmacol       Date:  2008-11-06       Impact factor: 4.600

8.  Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle.

Authors:  Donna M Platt; James K Rowlett; Roger D Spealman
Journal:  J Pharmacol Exp Ther       Date:  2009-12-04       Impact factor: 4.030

9.  Cocaine withdrawal-induced anxiety in females: impact of circulating estrogen and potential use of delta-opioid receptor agonists for treatment.

Authors:  Lisa M Ambrose-Lanci; R C Sterling; Elisabeth J Van Bockstaele
Journal:  J Neurosci Res       Date:  2010-03       Impact factor: 4.164

10.  Self-administration of drug mixtures by monkeys: combining drugs with comparable mechanisms of action.

Authors:  W L Woolverton; Zhixia Wang; Theresa Vasterling; F Ivy Carroll; Ronald Tallarida
Journal:  Psychopharmacology (Berl)       Date:  2007-11-20       Impact factor: 4.530

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