Literature DB >> 3788408

Alpha 1 acid glycoprotein in streptozotocin diabetic rats. Some aspects of sugar moiety structure and metabolism.

A Guzdek, M Pawlonka, J Noworytko.   

Abstract

The pure alpha 1 acid glycoprotein (AGP) preparation from streptozotocin diabetic rat sera showed diminished sialic acid content and lower ratios of galactose to mannose and galactose to fucose. In vivo incorporation of 14C-leucine and 3H-galactose into AGP of control and diabetic animals was studied 30, 60 and 120 min after administration of the radioisotopic precursors. The changed 14C/3H ratio in AGP of diabetic rats suggested disturbed glycosylation of AGP in this disease. Similar activity of UDP-galactose 4-epimerase in control and diabetic rat liver was found suggesting that this enzyme has no influence on the decreased level of serum protein bound galactose.

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Year:  1986        PMID： 3788408     DOI： 10.1007/bf02624711

Source DB:  PubMed          Journal:  Acta Diabetol Lat        ISSN： 0001-5563


  20 in total

1.  The enzymic interconversion of uridine diphosphogalactose and uridine diphosphoglucose.

Authors:  E S MAXWELL
Journal:  J Biol Chem       Date:  1957-11       Impact factor: 5.157

2.  Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate.

Authors:  R T Swank; K D Munkres
Journal:  Anal Biochem       Date:  1971-02       Impact factor: 3.365

3.  Structures of glycopeptides from a glycoprotein from bovine aorta.

Authors:  B Radhakrishnamurthy; G S Berenson
Journal:  J Biol Chem       Date:  1973-03-25       Impact factor: 5.157

4.  Neutral sugar composition of the seromucoid and non-diffusible blood sugar-peptide fractions in streptozotocin diabetic rats.

Authors:  B Turyna; M Sarnecka-Keller; M Jurewicz
Journal:  Horm Metab Res       Date:  1981-10       Impact factor: 2.936

5.  Serum-free and protein-bound sugars and cardiovascular complications in diabetes mellitus.

Authors:  B Radhakrishnamurthy; G S Berenson; P S Pargaonkar; A W Voors; S R Srinivasan; F Plavidal; P Dolan; E R Dalferes
Journal:  Lab Invest       Date:  1976-02       Impact factor: 5.662

6.  The physicochemical and chemical properties of alpha 1-acid glycoproteins from mammalian and avian plasmas.

Authors:  P A Charlwood; M W Hatton; E Regoeczi
Journal:  Biochim Biophys Acta       Date:  1976-11-26

7.  Sugar constituents of the seromucoid in insulin-dependent diabetes.

Authors:  B Turyna; M Sarnecka-Keller; T Ciba
Journal:  Exp Clin Endocrinol       Date:  1984-03

8.  Some properties of galactokinase in developing rat liver.

Authors:  D G Walker; H H Khan
Journal:  Biochem J       Date:  1968-06       Impact factor: 3.857

9.  Th activities of perfused livers of control and streptozotocin diabetic rats in the synthesis of some plasma proteins and peptides.

Authors:  A Guzdek; M Sarnecka-Keller; A Dubin
Journal:  Horm Metab Res       Date:  1979-02       Impact factor: 2.936

10.  The effects of streptozotocin diabetes on the activities of rat liver glycosyltransferases.

Authors:  H M Tepperman; J DeWitt; J Tepperman
Journal:  Diabetes       Date:  1983-05       Impact factor: 9.461
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