[Significance of carcinoembryonic antigen in the treatment of colorectal cancers].

Carcino-embryonic antigen (CEA) has been tested in numerous clinical studies, from its discovery in 1965. In the context of treatment for colorectal carcinoma, its importance is primarily related to early detection of recurrences following potentially curative operations. However, its value was found to be limited in primary diagnosis. In certain cases, second-look laparotomy may be indicated solely on the basis of rising CEA levels. Further clinical studies will have to be conducted under controlled conditions, with the view to finding out, if early detection of recurrences or metastasation is really beneficial to the patient in terms of extended survival.