Literature DB >> 378777

Rate of disappearance in plasma of synthetic LH-RH intravenously injected in man.

J P Fauconnier, B Teuwissen, K Thomas.   

Abstract

The rate of disappearance of intravenously injected LH-RH was studied in 6 human volunteers. The blood samples were taken every 20 sec from the time of injection to time +5 min and every 30 sec from time +5 min to time +10 min. The half-life of LH-RH was calculated in the interval of 3-10 min, and was found to be 2.4 +/- 0.4 min. The amounts of LH-RH estimated in the vascular compartment were relatively low when compared to the total amount of injected LH-RH. This observation suggests a rapid and important passage towards the extravascular compartment.

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Year:  1978        PMID： 378777     DOI： 10.1159/000300989

Source DB:  PubMed          Journal:  Gynecol Obstet Invest        ISSN： 0378-7346            Impact factor:   2.031


  5 in total

1.  Identification of a regulatory loop for the synthesis of neurosteroids: a steroidogenic acute regulatory protein-dependent mechanism involving hypothalamic-pituitary-gonadal axis receptors.

Authors:  Sivan Vadakkadath Meethal; Tianbing Liu; Hsien W Chan; Erika Ginsburg; Andrea C Wilson; Danielle N Gray; Richard L Bowen; Barbara K Vonderhaar; Craig S Atwood
Journal:  J Neurochem       Date:  2009-05-29       Impact factor: 5.372

Review 2.  The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive disease.

Authors:  Craig S Atwood; Richard L Bowen
Journal:  Horm Behav       Date:  2015-07-16       Impact factor: 3.587

Review 3.  The gonadotropin connection in Alzheimer's disease.

Authors:  Sivan Vadakkadath Meethal; Mark A Smith; Richard L Bowen; Craig S Atwood
Journal:  Endocrine       Date:  2005-04       Impact factor: 3.633

Review 4.  Gonadotropin-releasing hormone receptor system: modulatory role in aging and neurodegeneration.

Authors:  Liyun Wang; Wayne Chadwick; Sung-Soo Park; Yu Zhou; Nathan Silver; Bronwen Martin; Stuart Maudsley
Journal:  CNS Neurol Disord Drug Targets       Date:  2010-11       Impact factor: 4.388

5.  Estrogen induced enhancement of LHRH clearance in amenorrheic women.

Authors:  A Miyake; Y Kawamura; T Aono
Journal:  J Endocrinol Invest       Date:  1982 Jul-Aug       Impact factor: 4.256
  5 in total

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