A quantitative study of normal locomotion in the rat.

Three variables of locomotion; stride length, stride frequency and velocity have been measured in forty-eight rats. Median values were found to be 11.3 cm, 2.4 Hz and 24.2 cm/sec respectively. The results are assessed both as independent variables and in terms of their interaction. It was found that the two variables used to increase velocity (stride length and stride frequency) were not deployed equally during normal walking velocities (10-50 cm/sec). It is proposed that the study of these three readily quantifiable variables, particularly the relationships between velocity and stride frequency may be useful for the evaluation of locomotion in the assessment of neuropharmacologically active agents.