Age incidence of senile brain amyloidosis.

Neuropathological examination of 1400 successive autopsies in general and mental hospitals revealed that senile plaques and congophilic angiopathy are age related phenomena. There is, however, a remarkable difference between the two types of manifestation of senile amyloidosis. There was a significantly higher incidence of senile plaques in females. Moreover the increase of the incidence with age was also significantly higher in females. Congophilic angiopathy showed no predominance in females. In total 59% of males and 55% of females with senile plaques suffered from Senile Dementia of the Alzheimer Type (SDAT). SDAT appeared to be also an age related phenomenon characterized by a linear increase with age and a predominance in females.