Literature DB >> 3785486

Animal model of adenine-induced chronic renal failure in rats.

T Yokozawa, P D Zheng, H Oura, F Koizumi.   

Abstract

Long-term feeding of adenine to rats produced metabolic abnormalities resembling chronic renal failure in humans. Among the disturbances produced were azotemia, accumulation of uremic toxins, metabolic imbalances of amino acids and electrolytes, and hormonal imbalances. The pathological findings in the kidneys of these experimental rats revealed lesions of proximal tubules, of some distal tubules and of glomeruli. Contracted kidneys were found in the rats with severe perturbations. Our results suggest that long-term adenine feeding provides a model which would be useful to study chronic renal failure.

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Year:  1986        PMID： 3785486     DOI： 10.1159/000183992

Source DB:  PubMed          Journal:  Nephron        ISSN： 1660-8151            Impact factor:   2.847


  76 in total

1.  Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy.

Authors:  Z Yan; Y Zhang; D Duan; J F Engelhardt
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

2.  High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy.

Authors:  Yoko Oyama; Teruto Hashiguchi; Noboru Taniguchi; Salunya Tancharoen; Tomonori Uchimura; Kamal K Biswas; Ko-Ichi Kawahara; Takao Nitanda; Yoshihisa Umekita; Martin Lotz; Ikuro Maruyama
Journal:  Lab Invest       Date:  2010-03-15       Impact factor: 5.662

3.  Adenine acts in the kidney as a signaling factor and causes salt- and water-losing nephropathy: early mechanism of adenine-induced renal injury.

Authors:  Ingrid F Dos Santos; Sulaiman Sheriff; Sihame Amlal; Rafeeq P H Ahmed; Charuhas V Thakar; Hassane Amlal
Journal:  Am J Physiol Renal Physiol       Date:  2019-01-09

4.  Protection of Chinese herbs against adenine-induced chronic renal failure in rats.

Authors:  Yanqing Tong; Bing Han; Hongyang Guo; Yanru Liu
Journal:  Afr J Tradit Complement Altern Med       Date:  2010-07-03

5.  Matrix Gla protein metabolism in vascular smooth muscle and role in uremic vascular calcification.

Authors:  Koba A Lomashvili; Xiaonan Wang; Reidar Wallin; W Charles O'Neill
Journal:  J Biol Chem       Date:  2011-06-24       Impact factor: 5.157

6.  Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.

Authors:  Li-Juan Duan; Kotaro Takeda; Guo-Hua Fong
Journal:  Am J Pathol       Date:  2014-02-06       Impact factor: 4.307

7.  Chinese herbal medicine Shenqi Detoxification Granule inhibits fibrosis in adenine induced chronic renal failure rats.

Authors:  Min Peng; Pingping Cai; Hongbo Ma; Hongyan Meng; Yuan Xu; Xiaoyi Zhang; Guomin Si
Journal:  Afr J Tradit Complement Altern Med       Date:  2013-11-02

8.  Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification.

Authors:  K A Lomashvili; P Garg; S Narisawa; J L Millan; W C O'Neill
Journal:  Kidney Int       Date:  2008-02-20       Impact factor: 10.612

9.  Creatol (5-hydroxycreatinine), a new toxin candidate in uremic patients.

Authors:  K Nakamura; K Ienaga
Journal:  Experientia       Date:  1990-05-15

10.  Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease.

Authors:  Oleh Akchurin; Angara Sureshbabu; Steve B Doty; Yuan-Shan Zhu; Edwin Patino; Susanna Cunningham-Rundles; Mary E Choi; Adele Boskey; Stefano Rivella
Journal:  Am J Physiol Renal Physiol       Date:  2016-07-20
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